Department of Ophthalmology, the First Affiliated Hospital, Harbin Medical University, China.
Am J Perinatol. 2013 Nov;30(10):795-804. doi: 10.1055/s-0032-1333406. Epub 2013 Jan 17.
Polymorphisms in endothelial nitric oxide synthase (eNOS) gene may affect the risk of preeclampsia. This systematic review aimed to provide an updated review of the literature to better understand the association between the eNOS gene polymorphisms and the risk of preeclampsia. We searched electronic databases of the human literature in PubMed, EMBASE, and the Cochrane Library up to July 2012. A meta-analysis was conducted on the association of eNOS G894T, T786C, and intron 4b/a polymorphisms with preeclampsia using (1) allele contrast, (2) recessive, (3) dominant, and (4) additive models. Thirty-three studies comprising 10,671 participants met the inclusion criteria. There was statistically significant association between the G894T variant and increased risk of preeclampsia (TT versus TG + GG: odds ratio 1.43, 95% confidence interval: 1.13 to 1.82). However, no significant risk of preeclampsia was observed either in the T786C or the intron 4b/a polymorphism. Homozygosity TT in eNOS G894T variant is significantly associated with an increased risk of preeclampsia.
内皮型一氧化氮合酶（eNOS）基因多态性可能影响子痫前期的风险。本系统评价旨在对文献进行更新综述，以更好地了解 eNOS 基因多态性与子痫前期风险之间的关系。我们检索了人类文献电子数据库 PubMed、EMBASE 和 Cochrane Library，检索时间截至 2012 年 7 月。采用（1）等位基因对比、（2）隐性、（3）显性和（4）加性模型，对 eNOS G894T、T786C 和内含子 4b/a 多态性与子痫前期的相关性进行了荟萃分析。符合纳入标准的研究有 33 项，共包括 10671 名参与者。G894T 变异与子痫前期风险增加之间存在统计学显著关联（TT 与 TG+GG：比值比 1.43，95%置信区间：1.13 至 1.82）。然而，T786C 或内含子 4b/a 多态性与子痫前期风险无关。内皮型一氧化氮合酶 G894T 变异的纯合子 TT 与子痫前期风险增加显著相关。
