Waker Christopher A, Hwang Amy E, Bowman-Gibson Scout, Chandiramani Chandni H, Linkous Bryce, Stone Madison L, Keoni Chanel I, Kaufman Melissa R, Brown Thomas L
Department of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine, Wright State University, Dayton, OH, United States.
Department of Obstetrics and Gynecology, Boonshoft School of Medicine, Wright State University, Dayton, OH, United States.
Front Physiol. 2023 Apr 6;14:1137058. doi: 10.3389/fphys.2023.1137058. eCollection 2023.
Preeclampsia is a pregnancy-specific condition and a leading cause of maternal and fetal morbidity and mortality. It is thought to occur due to abnormal placental development or dysfunction, because the only known cure is delivery of the placenta. Several clinical risk factors are associated with an increased incidence of preeclampsia including chronic hypertension, diabetes, autoimmune conditions, kidney disease, and obesity. How these comorbidities intersect with preeclamptic etiology, however, is not well understood. This may be due to the limited number of animal models as well as the paucity of studies investigating the impact of these comorbidities. This review examines the current mouse models of chronic hypertension, pregestational diabetes, and obesity that subsequently develop preeclampsia-like symptoms and discusses how closely these models recapitulate the human condition. Finally, we propose an avenue to expand the development of mouse models of preeclampsia superimposed on chronic comorbidities to provide a strong foundation needed for preclinical testing.
子痫前期是一种与妊娠相关的疾病，是孕产妇和胎儿发病及死亡的主要原因。其发病被认为是由于胎盘发育异常或功能障碍所致，因为目前已知的唯一治疗方法是娩出胎盘。子痫前期发病率增加与多种临床风险因素相关，包括慢性高血压、糖尿病、自身免疫性疾病、肾脏疾病和肥胖。然而，这些合并症如何与子痫前期的病因相互作用，目前尚不清楚。这可能是由于动物模型数量有限，以及研究这些合并症影响的研究较少。本综述探讨了目前随后会出现子痫前期样症状的慢性高血压、孕前糖尿病和肥胖的小鼠模型，并讨论了这些模型与人类疾病的相似程度。最后，我们提出了一条途径，以扩大子痫前期叠加慢性合并症小鼠模型的开发，为临床前试验提供坚实的基础。
