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给编辑的图片信:穆林线状皮肤萎缩症46年来进展缓慢。

Photoletter to the editor: Linear atrophoderma of Moulin progressing slowly over 46 years.

作者信息

Afshar Maryam, Melancon Jeff, Hata Tissa

机构信息

Division of Dermatology, Department of Medicine, University of California San Diego, USA.

出版信息

J Dermatol Case Rep. 2012 Dec 31;6(4):125-6. doi: 10.3315/jdcr.2012.1121.

Abstract

Linear atrophoderma of Moulin is a rare acquired disorder arising most commonly during childhood or adolescence, occurring equally in both sexes and characterized by hyperpigmented atrophoderma in a unilateral bandlike distribution along the lines of Blaschko. Since Moulin et al described the condition in 1992, only a few dozen cases have been reported. It has been postulated that linear atrophoderma of Moulin may be due to mosaicism.A 66-year-old man pre-sen-ted with a 46-year his-to-ry of evol-ving tan soft atro-phic con-fluent plaques in a striking-ly Blasch-koid dis-tri-bu-tion, in-vol-ving the left up-per back, shoulder, up-per arm, chest and flank. Ini-tial on-set, at age 20, con-sis-ted of a single mildly pru-ritic pink patch on the left back that was un-res-pon-sive to topical anti-fun-gals. Each new le-sion arose simi-larly as a pink pru-ritic patch, sub-se-quent-ly be-co-ming de-pressed, hy-per-pig-men-ted, and asym-pto-ma-tic over se-ve-ral years. Le-sions were never scaly, firm, or indu-rated. Punch biopsy speci-mens were obtained. The clinical and histo-patho-lo-gi-cal features con-firmed the diagnosis of linear atrophoderma of moulin.Our present case has the characteristic clinical and histopathological features of linear atrophoderma of Moulin, but is the first reported case with mild pruritus at the onset of each new lesion and progressing slowly over 46 years. The lack of any systemic symptoms or other complications in our patient reaffirms the benign nature of this skin disease.

摘要

穆林线状皮肤萎缩症是一种罕见的后天性疾病,最常见于儿童期或青春期,男女发病率相同,其特征为沿着布拉斯科线呈单侧带状分布的色素沉着性皮肤萎缩。自1992年穆林等人描述该病症以来,仅报告了几十例病例。据推测,穆林线状皮肤萎缩症可能是由于嵌合体所致。一名66岁男性,有46年病史,其左上部背部、肩部、上臂、胸部和胁腹出现明显布拉斯科线样分布的逐渐发展的棕褐色柔软萎缩性融合斑块。最初发病于20岁时,表现为左背部单个轻度瘙痒的粉红色斑块,局部抗真菌治疗无效。每个新病变最初同样表现为粉红色瘙痒斑块,随后在几年内逐渐凹陷、色素沉着且无症状。病变从未出现鳞屑、变硬或硬结。进行了钻孔活检取材。临床和组织病理学特征证实为穆林线状皮肤萎缩症。我们目前的病例具有穆林线状皮肤萎缩症的典型临床和组织病理学特征,但却是首例每个新病变起始有轻度瘙痒且病程长达46年进展缓慢的病例。我们患者无任何全身症状或其他并发症,再次证实了这种皮肤病的良性本质。

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Linear atrophoderma of Moulin on the neck.颈部的穆林线性皮肤萎缩
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