Tang Chenyu, Wang Ping
Department of Dermatology, Hangzhou Third People's Hospital, Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Department of Dermatology, Hangzhou Third People's Hospital; Affiliated Hangzhou Dermatology Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Jan 21;16:193-196. doi: 10.2147/CCID.S398441. eCollection 2023.
Linear atrophoderma of Moulin (LAM) is a rare acquired skin disease. Clinically, LAM is characterized by hyperpigmented and atrophic unilateral band-like or linear dermatoses of variable size following the Blaschko lines. The lesions do not present induration or sclerosis. Its course is asymptomatic without systemic involvement or progression. The etiology of LAM is still unclear. Based on the characteristics of its skin lesions distributed along the Blaschko lines, some scholars speculate that its pathogenesis may be related to chromosome mosaicism. We hereby present a case report of LAM in a 29-year-old Chinese female who had persistent brown patches distributed along the Blaschko lines on the left lower back, buttocks, and lower limbs with positive antinuclear antibody (ANA, 1:320, nucleolar type) and elevated immunoglobulin M (3.47 g/L). Including this case, a total of 6 LAM cases have been reported to have abnormal serum immunological markers.
穆林线状皮肤萎缩症（LAM）是一种罕见的获得性皮肤病。临床上，LAM的特征是沿布拉斯科线出现大小不一的色素沉着和萎缩性单侧带状或线状皮肤病。病变无硬结或硬化。其病程无症状，无全身受累或进展。LAM的病因仍不清楚。基于其沿布拉斯科线分布的皮肤病变特征，一些学者推测其发病机制可能与染色体镶嵌现象有关。我们在此报告一例29岁中国女性的LAM病例，该患者左下腹、臀部和下肢沿布拉斯科线有持续的褐色斑块，抗核抗体阳性（ANA，1:320，核仁型），免疫球蛋白M升高（3.47 g/L）。包括该病例在内，共有6例LAM病例报告有血清免疫标志物异常。
