Zamorskii I I, Sopova I Yu, Khavinson V Kh
Bukovinian State Medical University, Chernovtsy, Ukraine.
Bull Exp Biol Med. 2012 Nov;154(1):51-3. doi: 10.1007/s10517-012-1873-7.
The effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in the cortex and hippocampus of hypoxic rats were studied under conditions of acute hypobaric hypoxia equivalent to the altitude of 12,000 m. Pineal preparations reduced the intensity of free-radical processes in the brain exposed to acute hypoxia. Epithalamin more effectively than exogenous melatonin protected hippocampal neurons during acute hypoxia by reducing free-radical damage to lipids and proteins.
在相当于海拔12000米的急性低压缺氧条件下，研究了褪黑素和表胚素对缺氧大鼠皮质和海马中蛋白质含量及脂质过氧化产物的影响。松果体制剂降低了暴露于急性缺氧环境下大脑中自由基过程的强度。在急性缺氧期间，表胚素通过减少脂质和蛋白质的自由基损伤，比外源性褪黑素更有效地保护海马神经元。
