子痫前期胎盘结构中抗血管生成因子的表达
Expression of antiangiogenic factors in the placental structures in pre-eclampsia.
作者信息
Shchyogolev A I, Dubova E A, Pavlova K A, Lyapin V M, Sukhikh G T
机构信息
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health and Social Development of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2012 Dec;154(2):287-91. doi: 10.1007/s10517-012-1932-0.
Comparative morphological study of the placentas was carried out in women with pregnancy aggravated by the development of pre-eclampsia. Immunohistochemical methods showed increased expression of endoglin (CD105) and VEGFR1 in all placental structures. The intensity of endoglin and VEGFR1 expression was maximum in the syncytiotrophoblast and extravillous cytotrophoblast cells in severe pre-eclampsia.
对因子痫前期发展而加重妊娠的女性胎盘进行了比较形态学研究。免疫组织化学方法显示，所有胎盘结构中内皮糖蛋白（CD105）和血管内皮生长因子受体1（VEGFR1）的表达均增加。在重度子痫前期中，合体滋养层细胞和绒毛外细胞滋养层细胞中内皮糖蛋白和VEGFR1的表达强度最高。
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