Renal, Molecular, and Vascular Medicine Divisions, Department of Medicine, Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Adv Chronic Kidney Dis. 2013 May;20(3):265-70. doi: 10.1053/j.ackd.2013.02.003.
Preeclampsia affects 3% to 5% of all pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. This disorder is characterized by a constellation of signs and symptoms, most notably new-onset hypertension and proteinuria during the last trimester of pregnancy. In this review, the molecular mechanisms of preeclampsia with an emphasis on the role of circulating antiangiogenic proteins in the pathogenesis of preeclampsia and its complications will be discussed.
子痫前期影响所有妊娠的 3%至 5%，是全世界孕产妇和围生期发病率和死亡率的主要原因。这种疾病的特征是一系列的体征和症状，最明显的是在妊娠最后三个月出现新发生的高血压和蛋白尿。在这篇综述中，我们将重点讨论子痫前期的分子机制，特别是循环抗血管生成蛋白在子痫前期及其并发症发病机制中的作用。
