Batysheva T T, Paskhina I N, Pshemyskaia I A, Kurenkov A L, Domonova E A, Sil'veĭstrova O Iu, Shipulina O Iu
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(7 Pt 2):77-83.
Ninety children, aged from 7 days to 12 months, with perinatal damage of the central nervous system (CNS) were virologically tested. The persistence of cytomegalovirus (CMV) DNA in the blood, urine and oropharyngeal swabs was identified in 18.9% of children. In 14.4% of children, CMV DNA was found only in oropharyngeal swabs and urine samples. In some cases, the severity of neurologic symptoms and absence of positive changes in the restoration treatment could be caused by the activity of CMV infection, blood CMV DNA and the increase in blood-brain barrier permeability. The authors recommend performance of a comprehensive immunological and molecular-biological survey in patients with suspected CMV infection. In case of positive reactions, a specific antiviral treatment should be started. Tree clinical cases are reported.
对90名年龄在7天至12个月之间、患有围生期中枢神经系统（CNS）损伤的儿童进行了病毒学检测。在18.9%的儿童中发现巨细胞病毒（CMV）DNA在血液、尿液和口咽拭子中持续存在。在14.4%的儿童中，仅在口咽拭子和尿液样本中发现CMV DNA。在某些情况下，神经症状的严重程度以及恢复治疗中缺乏积极变化可能是由CMV感染的活性、血液CMV DNA以及血脑屏障通透性增加引起的。作者建议对疑似CMV感染的患者进行全面的免疫学和分子生物学检查。如果反应呈阳性，应开始进行特异性抗病毒治疗。报告了3例临床病例。
