School of Science and Health, University of Western Sydney, Locked Bag 1797, Penrith, NSW, 2751, Australia.
BMC Med Res Methodol. 2013 Jan 19;13:7. doi: 10.1186/1471-2288-13-7.
Systematic reviews provide clinical practice recommendations that are based on evaluation of primary evidence. When systematic reviews with the same aims have different conclusions, it is difficult to ascertain which review reported the most credible and robust findings.
This study examined five systematic reviews that have investigated the effectiveness of Pilates exercise in people with chronic low back pain. A four-stage process was used to interpret findings of the reviews. This process included comparison of research questions, included primary studies, and the level and quality of evidence of systematic reviews. Two independent reviewers assessed the level of evidence and the methodological quality of systematic reviews, using the National Health and Medical Research Council hierarchy of evidence, and the Revised Assessment of Multiple Systematic Reviews respectively. Any disagreements were resolved by a third researcher.
A high level of consensus was achieved between the reviewers. Conflicting findings were reported by the five systematic reviews regarding the effectiveness of Pilates in reducing pain and disability in people with chronic low back pain. Authors of the systematic reviews included primary studies that did not match their questions in relation to treatment or population characteristics. A total of ten primary studies were identified across five systematic reviews. Only two of the primary studies were included in all of the reviews due to different inclusion criteria relating to publication date and status, definition of Pilates, and methodological quality. The level of evidence of reviews was low due to the methodological design of the primary studies. The methodological quality of reviews varied. Those which conducted a meta-analysis obtained higher scores.
There is inconclusive evidence that Pilates is effective in reducing pain and disability in people with chronic low back pain. This is due to the small number and poor methodological quality of primary studies. The Revised Assessment of Multiple Systematic Reviews provides a useful method of appraising the methodological quality of systematic reviews. Individual item scores, however, should be examined in addition to total scores, so that significant methodological flaws of systematic reviews are not missed, and results are interpreted appropriately. (348 words).
系统评价提供基于对原始证据评估的临床实践建议。当具有相同目的的系统评价得出不同的结论时,很难确定哪项评价报告了最可信和最可靠的发现。
本研究对五项调查普拉提运动对慢性下背痛患者有效性的系统评价进行了检查。采用四阶段过程来解释评价结果。该过程包括比较研究问题、纳入的主要研究以及系统评价的证据水平和质量。两名独立评审员使用澳大利亚国家卫生和医疗研究委员会的证据等级和修订后的多个系统评价评估系统评价的证据水平和方法学质量。任何分歧均由第三名研究人员解决。
评审员之间达成了高度共识。五项系统评价报告了普拉提对降低慢性下背痛患者疼痛和残疾的有效性存在冲突的结果。系统评价的作者纳入了与其治疗或人群特征相关的问题不匹配的主要研究。五项系统评价共确定了十项主要研究。由于与出版日期和状态、普拉提定义以及方法学质量有关的不同纳入标准,只有两项主要研究被所有五项系统评价纳入。由于主要研究的方法学设计,评价的证据水平较低。评价的方法学质量参差不齐。进行荟萃分析的评价获得了更高的分数。
没有确凿的证据表明普拉提可有效降低慢性下背痛患者的疼痛和残疾。这是由于主要研究的数量少且方法学质量差。修订后的多个系统评价评估提供了一种评估系统评价方法学质量的有用方法。然而,除了总分外,还应检查个别项目的分数,以免错过系统评价的重大方法学缺陷,并适当解释结果。(348 字)