妊娠人子宫肌的体视学研究：母体体重指数和年龄的影响。
Stereology of human myometrium in pregnancy: influence of maternal body mass index and age.
机构信息
Department of Obstetrics and Gynecology, National University of Ireland Galway, Galway University Hospital, Galway, Ireland.
出版信息
Am J Obstet Gynecol. 2013 Apr;208(4):324.e1-6. doi: 10.1016/j.ajog.2013.01.019. Epub 2013 Jan 17.
OBJECTIVE
Knowledge of the stereology of human myometrium in pregnancy is limited. Uterine contractile performance may be altered in association with maternal obesity and advanced maternal age. The aim of this study was to investigate the stereology of human myometrium in pregnancy, and to evaluate a potential influence of maternal body mass index (BMI) and age.
STUDY DESIGN
Biopsies of human myometrium were obtained from 57 women at cesarean section (n = 26, n = 13, n = 18 normal, overweight and obese BMI, respectively), and volume fractions of smooth muscle and extracellular matrix were assessed using stereologic techniques.
RESULTS
The smooth muscle constituted 65.2% ± 8.9% (standard deviation) and the extracellular matrix 32.6% ± 7.7% (standard deviation) (n = 57). There was no correlation observed between maternal BMI, age, or parity with the fractional volumes of either smooth muscle or extracellular matrix.
CONCLUSION
These results outline the stereology of human myometrium in pregnancy. Putative functional differences in contractility, pertaining to obese or older mothers, are not related to smooth muscle content.
目的
人类妊娠子宫肌层的体视学知识有限。子宫收缩性能可能会随着母体肥胖和高龄而改变。本研究旨在探讨妊娠子宫肌层的体视学，并评估母体体重指数（BMI）和年龄的潜在影响。
研究设计
通过剖宫产术从 57 名妇女中获得人子宫肌层活检（n=26，n=13，n=18 分别为正常、超重和肥胖 BMI），并使用体视学技术评估平滑肌和细胞外基质的体积分数。
结果
平滑肌占 65.2%±8.9%（标准差），细胞外基质占 32.6%±7.7%（标准差）（n=57）。母亲 BMI、年龄或产次与平滑肌或细胞外基质的分体积之间没有观察到相关性。
结论
这些结果概述了人类妊娠子宫肌层的体视学。与肥胖或年长母亲相关的收缩性潜在功能差异与平滑肌含量无关。
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