Department of Pathophysiology, Jilin University, Changchun, China.
Asian J Androl. 2013 Mar;15(2):218-20. doi: 10.1038/aja.2012.130. Epub 2013 Jan 21.
The PSA screening for 25 years in America is the biggest cohort study in a field of public health.27 We should realize not only the significance of the early diagnosis and treatment of PCa, but also the dramatic decrease in PCaMR from 2002 to 2008. The data from the IARC were especially noteworthy.Moreover, the patients with highly aggressive PCa, who account for more than 30% of all PCa patients, could only be diagnosed earlier by PSA screening. The patients would thus gain the opportunity for earlier treatment and would have a prolonged, higher quality life-span. However, the complications of interventional treatments, including biopsy,radical prostatectomy and/or radiation therapy,will become more avoidable in the near future.According to the supporting evidence for the decrease in PCa mortality in PSA screening, we strongly hope that the USPSTF changes the 'D' recommendation for PSA screening.
美国开展了长达 25 年的 PSA 筛查，这是公共卫生领域最大的队列研究。27 我们不仅应该认识到 PCa 早期诊断和治疗的重要意义，还应该认识到 2002 年至 2008 年期间 PCaMR 的显著下降。国际癌症研究机构的数据尤其值得关注。此外，超过 30%的所有前列腺癌患者都患有高度侵袭性前列腺癌，只有通过 PSA 筛查才能更早地诊断出来。这样，患者就有机会更早地接受治疗，并延长高质量的寿命。然而，包括活检、根治性前列腺切除术和/或放射治疗在内的介入治疗的并发症在不久的将来将变得更加可以避免。根据 PSA 筛查降低前列腺癌死亡率的支持证据，我们强烈希望 USPSTF 改变 PSA 筛查的“D”级推荐。
