Carol Davila University of Medicine, National Institute of Endocrinology, Bucharest, Romania.
Calcif Tissue Int. 2013 May;92(5):429-36. doi: 10.1007/s00223-013-9697-7. Epub 2013 Jan 19.
A FRAX(®) model for Romania calibrated to the total Romanian population was released June 1, 2011. This article describes the data used to develop the Romanian FRAX model and illustrates its features compared to models for other countries. Age- and sex-stratified hip fracture incidence rates and mortality rates for 2010 were extracted from nationwide databases from the age of 40 years. For other major fractures, Romanian incidence rates were imputed, using Swedish ratios for hip to other major osteoporotic fracture (humerus, forearm, and clinically symptomatic vertebral fractures). Fracture incidence rates increased with increasing age: for hip fracture, incidence rates were higher among younger men than women but with a female preponderance from the age of 65 years. The 10-year probability of hip or major fracture was increased in patients with a clinical risk factor (CRF), lower BMI, female gender, higher age, and decreased BMD T score. Of the CRFs, a parental hip fracture accounted for the greatest increase in 10-year fracture probability. The Romanian FRAX tool is the first country-specific fracture prediction model. It is based on the original FRAX methodology, which has been externally validated in several independent cohorts. Despite some limitations, the strengths make the Romanian FRAX tool a good candidate for implementation into clinical practice.
2011 年 6 月 1 日，发布了适用于罗马尼亚总人口的 Frax(®)模型。本文描述了开发罗马尼亚 Frax 模型所使用的数据，并说明了其与其他国家模型的特点。2010 年，从全国数据库中提取了 40 岁及以上人群的年龄和性别分层髋部骨折发生率和死亡率数据。对于其他主要骨折，使用瑞典髋部与其他主要骨质疏松性骨折（肱骨、前臂和有临床症状的椎体骨折）的比值来推断罗马尼亚的骨折发生率。骨折发生率随年龄增长而增加：对于髋部骨折，年轻男性的发生率高于女性，但从 65 岁起女性占优势。存在临床危险因素（CRF）、较低 BMI、女性、较高年龄和较低 BMD T 评分的患者，髋部或主要骨折的 10 年发生概率增加。在 CRF 中，父母髋部骨折导致 10 年骨折概率增加最大。罗马尼亚 Frax 工具是第一个国家特定的骨折预测模型。它基于原始 Frax 方法学，该方法学已在多个独立队列中得到外部验证。尽管存在一些局限性，但该模型的优势使其成为实施临床实践的良好候选者。
