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[通过免疫荧光和免疫过氧化物酶法在骨Paget病破骨细胞中证实存在麻疹类型抗原]

[Demonstration by immunofluorescence and immunoperoxidase of an antigen of the measles type in the osteoclasts of Paget's disease of bone].

作者信息

Basle M, Rebel A, Pouplard A, Kouyoumdjian S, Filmon R, Loepatezour A

出版信息

Bull Assoc Anat (Nancy). 1979 Sep;63(182):263-72.

PMID:233348
Abstract

The intra nuclear and intra cytoplasmic inclusions described in osteoclasts in PAGET's bone disease are morphologically similar to those observed in subacute sclerosing panencephalitis. Immunological techniques using different specific immune sera demonstrate the presence of an antigenic structure of viral origin in osteoclasts in PAGET's bone disease. A measles or a measles like virus is most likely to be involved and may play a role in the etiology of the disease.

摘要

佩吉特骨病破骨细胞内的核内和胞质内包涵体在形态上与亚急性硬化性全脑炎中观察到的包涵体相似。使用不同特异性免疫血清的免疫技术证明,佩吉特骨病破骨细胞中存在病毒来源的抗原结构。很可能涉及麻疹病毒或类麻疹病毒,它们可能在该疾病的病因中起作用。

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Towards a viral etiology for Paget's disease of bone.探索骨Paget病的病毒病因
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