5-HTTLPR：白衣骑士还是黑暗之殇？
5HTTLPR: White Knight or Dark Blight?
机构信息
Laboratory of Clinical Science, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States.
出版信息
ACS Chem Neurosci. 2013 Jan 16;4(1):13-5. doi: 10.1021/cn3002224.
Abstract
In over 100 neuroscience genetics reports on SLC6A4 published in the first part of 2012, >40% reported data from genotyping only the serotonin transporter-linked promoter region [5HTTLPR] indel, omitting genotyping of two nearby SNPs that substantially alter 5HTTLPR allele frequencies and functionality. And 25% of these papers did not report ethnicity of the subjects genotyped, another factor that alters allele frequencies. This field thus seems stultified. Improved science for the present and future will be better served by attention to more complete methods for genotyping and subject sample reporting.
摘要
在 2012 年上半年发表的超过 100 篇有关 SLC6A4 的神经科学遗传学报告中，超过 40% 的报告仅提供了血清素转运体相关启动子区域 [5HTTLPR] 插入缺失的基因分型数据，而忽略了两个附近的单核苷酸多态性（SNP）的基因分型，这两个 SNP 显著改变了 5HTTLPR 等位基因频率和功能。这些论文中有 25% 没有报告基因分型对象的种族，这是另一个改变等位基因频率的因素。因此，这个领域似乎陷入了僵局。通过关注更完整的基因分型和对象样本报告方法，将更好地为当前和未来的科学提供改进。
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