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表观遗传学及其对心理学的影响。

Epigenetics and its implications for Psychology.

机构信息

Universidad de Oviedo, Spain.

出版信息

Psicothema. 2013 Feb;25(1):3-12. doi: 10.7334/psicothema2012.327.

Abstract

BACKGROUND

Epigenetics is changing the widely accepted linear conception of genome function by explaining how environmental and psychological factors regulate the activity of our genome without involving changes in the DNA sequence. Research has identified epigenetic mechanisms mediating between environmental and psychological factors that contribute to normal and abnormal behavioral development.

METHOD

the emerging field of epigenetics as related to psychology is reviewed.

RESULTS

the relationship between genes and behavior is reconsidered in terms of epigenetic mechanisms acting after birth and not only prenatally, as traditionally held. Behavioral epigenetics shows that our behavior could have long-term effects on the regulation of the genome function. In addition, epigenetic mechanisms would be related to psychopathology, as in the case of schizophrenia. In the latter case, it would be especially relevant to consider epigenetic factors such as life adversities (trauma, disorganized attachment, etc.) as related to its clinical manifestations, rather than genetic factors. Moreover, epigenetics implies overcoming classical dualist dichotomies such as nature-nurture, genotype-phenotype or pathogenesis-pathoplasty.

CONCLUSIONS

In general, it can be stated that behavior and environment will finally take on a leading role in human development through epigenetic mechanisms.

摘要

背景

表观遗传学通过解释环境和心理因素如何在不改变 DNA 序列的情况下调节我们基因组的活性,改变了人们对基因组功能的普遍接受的线性概念。研究已经确定了介导环境和心理因素与正常和异常行为发展之间关系的表观遗传机制。

方法

综述了与心理学相关的新兴表观遗传学领域。

结果

根据出生后而非传统上认为的仅在产前起作用的表观遗传机制,重新考虑了基因与行为之间的关系。行为表观遗传学表明,我们的行为可能对基因组功能的调节产生长期影响。此外,表观遗传机制与精神病理学有关,如精神分裂症。在后一种情况下,特别需要考虑生活逆境(创伤、依恋紊乱等)等表观遗传因素与临床表现的关系,而不是遗传因素。此外,表观遗传学意味着克服了诸如天性-教养、基因型-表型或发病机制-病理生理学等经典二元对立。

结论

总的来说,可以说通过表观遗传机制,行为和环境最终将在人类发展中发挥主导作用。

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