Gross M E, Tranquilli W J, Thurmon J C, Benson G J, Olson W A
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois-Urbana 61801.
Vet Surg. 1990 Mar-Apr;19(2):173-80. doi: 10.1111/j.1532-950x.1990.tb01163.x.
The hemodynamic effects of a mixture of midazolam (1.0 mg/kg), xylazine (0.44 mg/kg), and butorphanol (0.1 mg/kg) were evaluated in six adult dogs. The dogs were anesthetized with isoflurane for instrumentation. As the dogs returned to consciousness, baseline values were recorded and the midazolam-xylazine-butorphanol mixture and glycopyrrolate (0.01 mg/kg) were administered intravenously (IV). Hemodynamic data were recorded 3, 10, 20, 30, 40, 50, and 60 minutes after injection. Mean arterial pressure (AP), mean pulmonary arterial pressure (PAP), heart rate (HR), rate-pressure product (RPP), mean pulmonary capillary wedge pressure (PCWP), systemic vascular resistance (SVR), and right ventricular stroke work index (RVSWI) were increased significantly above baseline values. Cardiac output (CO), stroke volume (SV), cardiac index (CI), stroke index (SI), mean central venous pressure (CVP), and left ventricular stroke work index (LVSWI) were decreased significantly below baseline values. When administered IV at the dosages used in this study, midazolam-xylazine-butorphanol-glycopyrrolate induced profound acute alterations in several critical hemodynamic variables.
在6只成年犬中评估了咪达唑仑（1.0毫克/千克）、赛拉嗪（0.44毫克/千克）和布托啡诺（0.1毫克/千克）混合物的血流动力学效应。这些犬用异氟烷麻醉以进行仪器植入。当犬恢复意识后，记录基线值，并静脉注射（IV）咪达唑仑 - 赛拉嗪 - 布托啡诺混合物和格隆溴铵（0.01毫克/千克）。在注射后3、10、20、30、40、50和60分钟记录血流动力学数据。平均动脉压（AP）、平均肺动脉压（PAP）、心率（HR）、速率 - 压力乘积（RPP）、平均肺毛细血管楔压（PCWP）、全身血管阻力（SVR）和右心室每搏功指数（RVSWI）显著高于基线值。心输出量（CO）、每搏量（SV）、心脏指数（CI）、每搏指数（SI）、平均中心静脉压（CVP）和左心室每搏功指数（LVSWI）显著低于基线值。在本研究使用的剂量下静脉给药时，咪达唑仑 - 赛拉嗪 - 布托啡诺 - 格隆溴铵在几个关键血流动力学变量中引起了深刻的急性改变。
