University of North Parana, Londrina, PR, Brazil.
Arch Oral Biol. 2013 Jul;58(7):806-12. doi: 10.1016/j.archoralbio.2012.12.010. Epub 2013 Jan 19.
To evaluate healing time before loading, areas compression and tension and location of insertion on mini-implant stability.
Six minipigs were used. Each animal received 3 mini-implants in each quadrant: 1 mini-implant was used as an unloaded control (G1, n=24); the other 2 were loaded with 150g-force at three time intervals (G2: immediate loading, G3: after 15 days and G4: after 30 days), with 16 mini-implant in each experimental group. After 120 days, tissue blocks of the areas of interest were harvested. Clinical analysis (exact Fisher test) determined the survival rate. Histological analysis (Kontron KS 300™, Zeiss) quantified the fractional bone-to-implant contact (%BIC) and bone area (%BA) at each healing time point, areas of interest, and insertion site (ANOVA and t tests for dependent and independent samples).
The mini-implant survival rates were G1: 71%, G2: 50%, G3: 75% and G4: 63%, with no statistical differences between them. The groups presented similar %BIC and %BA. There were no differences between the compression and tension sides or maxillary and mandibular insertion sites.
These results suggest that low-intensity immediate or early orthodontic loading does not affect mini-implant stability, because similar histomorphometric results were observed for all the groups, with partial osseointegration of the mini-implants present.
评估加载前愈合时间、区域压缩和张力以及插入位置对迷你种植体稳定性的影响。
使用 6 头小型猪。每头动物的每个象限各植入 3 枚迷你种植体：1 枚作为未加载对照（G1，n=24）；其余 2 枚在三个时间间隔加载 150g 力（G2：即刻加载，G3：15 天后，G4：30 天后），每组实验各有 16 枚迷你种植体。120 天后，采集感兴趣区域的组织块。临床分析（确切 Fisher 检验）确定存活率。组织学分析（Kontron KS 300™，Zeiss）量化了每个愈合时间点、感兴趣区域和插入部位的骨-种植体接触率（%BIC）和骨面积（%BA）（依赖和独立样本的 ANOVA 和 t 检验）。
迷你种植体存活率分别为 G1：71%、G2：50%、G3：75%和 G4：63%，各组之间无统计学差异。各组的%BIC 和 %BA 相似。压缩侧和张力侧以及上颌和下颌插入部位之间无差异。
这些结果表明，低强度即刻或早期正畸加载不会影响迷你种植体的稳定性，因为所有组均观察到相似的组织形态计量学结果，迷你种植体有部分骨整合。
