Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Eur J Vasc Endovasc Surg. 2013 Mar;45(3):293-8. doi: 10.1016/j.ejvs.2012.12.011. Epub 2013 Jan 20.
This study aims to investigate whether overweight and obesity are related to the clinical (C) category of clinical, etiologic, anatomic and pathophysiologic (CEAP) classification of chronic venous disease (CVD).
A cross-sectional study.
The study was conducted in Serbia, in the year 2011. Men and women aged >18 years, consecutively coming to venous specialists because of venous problems in the legs, were included in the study. Patients demographic, anthropometric and clinical data were collected. For the analysis, univariate and multivariate logistic regressions were used.
The study comprised 1116 subjects with primary CVD, 384 (34.4%) men and 732 (65.6%) women. Among them 464 (41.6%) were normal-weight patients (body mass index (BMI) < 25.0 kg m(-2)), 476 (42.7%) were overweight (BMI = 25.0-29.9 kg m(-2)) and 176 (15.8%) were obese (BMI ≥ 30.0 kg m(-2)). According to multivariate analysis, the CEAP C category of CVD was significantly more advanced in overweight and obese patients, the association being more pronounced in obese. Compared groups did not differ in the presence of venous reflux. In univariate analysis, venous obstruction was related to overweight and obesity but this association did not substantially affect the relationship between obesity and CEAP C categories of CVD.
The CEAP C categories of CVD were significantly related to overweight and obesity, and this association was independent of age, sex and some other postulated risk factors.
本研究旨在探讨超重和肥胖是否与慢性静脉疾病（CVD）的临床、病因、解剖和病理生理学（CEAP）分类的临床（C）类别有关。
横断面研究。
该研究于 2011 年在塞尔维亚进行。年龄>18 岁的男性和女性，因腿部静脉问题连续到静脉专科医生就诊，被纳入研究。收集患者的人口统计学、人体测量学和临床数据。为了分析，使用单变量和多变量逻辑回归。
该研究包括 1116 名患有原发性 CVD 的患者，其中 384 名（34.4%）为男性，732 名（65.6%）为女性。其中 464 名（41.6%）为正常体重患者（体重指数（BMI）<25.0 kg m(-2))，476 名（42.7%）为超重患者（BMI=25.0-29.9 kg m(-2))，176 名（15.8%）为肥胖患者（BMI≥30.0 kg m(-2))。根据多变量分析，超重和肥胖患者的 CVD 的 CEAP C 类别明显更为严重，肥胖患者的关联更为明显。比较组在静脉反流的存在方面没有差异。在单变量分析中，静脉阻塞与超重和肥胖有关，但这种关联并没有实质性地影响肥胖与 CVD 的 CEAP C 类别之间的关系。
CVD 的 CEAP C 类别与超重和肥胖显著相关，这种关联独立于年龄、性别和其他一些假定的危险因素。
