Department of Sport Education, Hokusho University, Ebetsu, Japan.
Circ J. 2013;77(2):293-300. doi: 10.1253/circj.cj-12-1235. Epub 2013 Jan 19.
Chronic heart failure (CHF) is characterized as a clinical disorder displaying exercise intolerance; patients typically complain of early muscular fatigue. Previously, it was thought to be simply a failure of perfusion to the exercising musculature and consequent early onset of intramuscular acidosis in CHF. However, improved hemodynamics by cardiotonic agents did not lead to an increase in exercise tolerance. Later studies have shown that intrinsic skeletal muscle abnormalities exist in patients with CHF and could induce the early anaerobic metabolism that limits exercise tolerance. We review the clinical importance of skeletal muscle abnormalities in patients with CHF. Considering the significance of peripheral muscle abnormalities and their development might help physicians and researchers better understand the mechanisms of well-established exercise training and pharmacological therapies that have been shown to improve the prognosis for CHF, and thus develop potential novel therapies.
慢性心力衰竭（CHF）的特征是一种表现为运动不耐受的临床疾病；患者通常会抱怨早期肌肉疲劳。以前，人们认为这只是运动肌肉灌注的失败，导致 CHF 中肌肉内酸中毒的早期发生。然而，强心剂改善血液动力学并不能提高运动耐量。后来的研究表明，CHF 患者存在内在的骨骼肌异常，可能导致限制运动耐量的早期无氧代谢。我们综述了骨骼肌异常在 CHF 患者中的临床重要性。考虑到周围肌肉异常及其发展的意义，可能有助于医生和研究人员更好地理解已被证明可改善 CHF 预后的既定运动训练和药物治疗的机制，从而开发潜在的新疗法。
