Ogawa Akihiro, Kanzaki Shinya, Ikeda Yuki, Iwakawa Masahiro, Nakagami Takahiro, Sato Shuji, Mikamo Hiroshi, Kido Satoshi, Nakajima Arata, Shimizu Kazuhiro
Department of Rehabilitation, Toho University Sakura Medical Center, 564-1, Shimoshizu, Sakura, Chiba 285-8741, Japan.
Graduate School of Health Sciences, Saitama Prefectural University, 820, Sannomiya, Koshigaya, Saitama 343-8540, Japan.
J Clin Med. 2023 Dec 21;13(1):42. doi: 10.3390/jcm13010042.
The relationship between arterial stiffness and oxygen uptake (VO) in patients with acute myocardial infarction (AMI) remains unclear. We aimed to investigate this relationship and factors contributing to VO in patients with AMI. The role of arterial stiffness in cardio-skeletal muscle coupling during exercise was then elucidated. Upon discharge, we measured exercise capacity using cardiopulmonary exercise testing (CPX), assessed arterial stiffness with the cardio-ankle vascular index (CAVI), and determined body composition to assess the skeletal muscle mass of 101 patients with AMI. Patients were categorized based on their CAVI scores into three groups: (i) normal (CAVI: ≤7.9), (ii) borderline (CAVI: 8.0-8.9), and (iii) abnormal (CAVI: ≥9.0). Subsequently, VO was compared among these groups. The relationship between the CAVI and VO during CPX and factors contributing to VO were investigated. The abnormal CAVI group had a significantly lower VO than the normal and borderline groups. The CAVI was associated with VO. Furthermore, the CAVI was found to be a factor contributing to VO. These findings suggest that arterial stiffness in tissue blood distribution and blood supply causes systemic exercise limits in patients with AMI. This suggests that arterial stiffness plays a significant role in cardio-vascular-skeletal muscle coupling.
急性心肌梗死（AMI）患者的动脉僵硬度与摄氧量（VO）之间的关系尚不清楚。我们旨在研究这种关系以及导致AMI患者VO的因素。随后阐明了运动期间动脉僵硬度在心脏-骨骼肌耦合中的作用。出院时，我们使用心肺运动试验（CPX）测量运动能力，用心踝血管指数（CAVI）评估动脉僵硬度，并测定身体成分以评估101例AMI患者的骨骼肌质量。根据CAVI评分将患者分为三组：（i）正常（CAVI：≤7.9），（ii）临界（CAVI：8.0 - 8.9），和（iii）异常（CAVI：≥9.0）。随后，比较这些组之间的VO。研究了CPX期间CAVI与VO之间的关系以及导致VO的因素。异常CAVI组的VO明显低于正常组和临界组。CAVI与VO相关。此外，发现CAVI是导致VO的一个因素。这些发现表明，组织血液分布和血液供应中的动脉僵硬度导致AMI患者的全身运动受限。这表明动脉僵硬度在心血管-骨骼肌耦合中起重要作用。
