Pedersen Line, Hansen Anneli Borge, Svendsen Kristian, Skurtveit Svetlana, Borchgrevink Petter C, Fredheim Olav Magnus S
National Competence Centre for Complex Symptom Disorders, Norwegian University of Science and Technology, Norway.
Tidsskr Nor Laegeforen. 2012 Nov 27;132(22):2489-93. doi: 10.4045/tidsskr.11.1214.
The prevalence of chronic non-malignant pain in Norway is between 24% and 30%. The proportion of the population using opioids for non-malignant pain on a long-term basis is around 1%. The purpose of our study was to investigate how many were prescribed analgesics on reimbursable prescription under reimbursement code -71 (chronic non-malignant pain) in 2009 and 2010, which analgesics were prescribed and whether prescribing practices were in accordance with national guidelines.
We retrieved pseudonymised data from the National Prescription Database on all those who received drugs with reimbursement code -71 in 2009 and 2010. The data contain information on drug, dosage, formulation, reimbursement code and date of issue.
90,731 patients received reimbursement for drugs indicated for chronic non-malignant pain in 2010. Of these, 6,875 were given opioids, 33,242 received paracetamol, 25,865 non-steroid inflammatory drugs (NSAIDs), 20,654 amitryptiline and 16,507 gabapentin. Oxycodone was the most frequently prescribed opioid, followed by buprenorphine, tramadol and codeine/paracetamol. Of those who were prescribed opioids, 4,047 (59%) received mainly slow-release opioids, 2,631 (38%) also received benzodiazepines and 2,418 (35%) received benzodiazepine-like sleep medications.
The number of patients who received analgesics and opioids on reimbursable prescriptions was low compared to the proportion of the population with chronic pain and the proportion using opioids long-term. 38% of those reimbursed for opioids also used benzodiazepines, which is contrary to official Norwegian guidelines.
挪威慢性非恶性疼痛的患病率在24%至30%之间。长期使用阿片类药物治疗非恶性疼痛的人口比例约为1%。我们研究的目的是调查2009年和2010年有多少人根据报销代码-71(慢性非恶性疼痛)获得了可报销处方的镇痛药,开具了哪些镇痛药,以及处方做法是否符合国家指南。
我们从国家处方数据库中检索了2009年和2010年所有使用报销代码-71的药物的患者的化名数据。这些数据包含有关药物、剂量、剂型、报销代码和开具日期的信息。
2010年有90,731名患者获得了用于慢性非恶性疼痛的药物报销。其中,6,875人使用了阿片类药物,33,242人使用了对乙酰氨基酚,25,865人使用了非甾体类抗炎药(NSAIDs),20,654人使用了阿米替林,16,507人使用了加巴喷丁。羟考酮是最常开具的阿片类药物,其次是丁丙诺啡、曲马多和可待因/对乙酰氨基酚。在开具阿片类药物的患者中,4,047人(59%)主要接受缓释阿片类药物,2,631人(38%)还接受了苯二氮䓬类药物,2,418人(35%)接受了类苯二氮䓬类助眠药物。
与慢性疼痛患者的比例和长期使用阿片类药物的比例相比,通过可报销处方获得镇痛药和阿片类药物的患者数量较少。38%的阿片类药物报销患者还使用了苯二氮䓬类药物,这与挪威官方指南相悖。