Oliveira Renata do Sacramento Monte de, Redorat Renato Galvão, Ziehe Gisele Hart, Mansur Vera Aleta, Conceição Flávia Lúcia
Endocrinology Section, Hospital Universitário Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Brazil.
Rev Bras Ginecol Obstet. 2013 Jan;35(1):21-6. doi: 10.1590/s0100-72032013000100005.
To evaluate parameters related with arterial pressure and metabolic profile in women with polycystic ovary syndrome (POS).
This monocentric study at the University Hospital Endocrinology Section included 60 women aged 18-45 years, 42 being diagnosed with POS and acting as 18 controls. All women were subjected to transvaginal ultrasound and monitored for arterial pressure for 24 h in the ambulatory (MAP). Venous blood samples were taken between 07.00 and 09.00, after 12 h fasting. Basal (BG) and fasting glucose concentrations, total cholesterol and its fractions, triglycerides and insulin (to calculate the homeostatic assay insulin-resistance, HOMA-IR) were measured. Collected data were the mean arterial blood pressure (24-h awake/sleep cycle), arterial pressure nocturnal descensus, glycemia and fasting glucose for HOMA-IR, and lipid profile. The Student's t test was used to compare homogeneous variables; the Mann-Whitney test was used to compare non-homogeneous variables; the Pearson's correlation coefficient was used to search for correlation between the variables. The χ(2) test was used for comparison of the absence of nocturnal descensus. Significance was taken as p<0.05.
The mean age of the patients with POS was 27.4 ± 5.5 (18-45 years, n=42) and the body mass index (BMI) was 30.2 ± 6.5 kg/m(2) (18.3-54.9). In the Control Group, the mean age was 31.4 ± 6.1 (18-45 years) and the BMI was 27.1 ± 6.2 kg/m(2) (18.3-54.9, n=18). No difference in the metabolic parameters and insulin resistance was observed between the two groups. Comparison between these parameters and MAP showed that the only parameter with a correlation was the BMI, independent of the POS diagnosis. This was not seen in nocturnal descensus, which was uncorrelated with POS and any of the other studied parameters.
POS women do not show higher arterial blood pressure, glycemia, HDL-col, TG, HOMA-IR and BMI compared to non-POS women. However, POS patients showed correlation between arterial pressure and BMI, suggesting that obesity is a primary factor involved in arterial pressure changes in these patients.
评估多囊卵巢综合征（PCOS）女性与动脉压和代谢谱相关的参数。
这项在大学医院内分泌科进行的单中心研究纳入了60名年龄在18 - 45岁的女性，其中42名被诊断为PCOS，18名作为对照。所有女性均接受经阴道超声检查，并在门诊进行24小时动脉压监测（平均动脉压，MAP）。在禁食12小时后的07:00至09:00采集静脉血样。测量基础血糖（BG）和空腹血糖浓度、总胆固醇及其组分、甘油三酯和胰岛素（用于计算稳态模型评估胰岛素抵抗，HOMA - IR）。收集的数据包括平均动脉血压（24小时清醒/睡眠周期）、夜间动脉压下降、血糖和用于HOMA - IR的空腹血糖以及血脂谱。采用Student's t检验比较同质变量；采用Mann - Whitney检验比较非同质变量；采用Pearson相关系数寻找变量之间的相关性。采用χ²检验比较夜间血压下降情况。以p < 0.05为有统计学意义。
PCOS患者的平均年龄为27.4 ± 5.5岁（18 - 45岁，n = 42），体重指数（BMI）为30.2 ± 6.5 kg/m²（18.3 - 54.9）。对照组的平均年龄为31.4 ± 6.1岁（18 - 45岁），BMI为27.1 ± 6.2 kg/m²（18.3 - 54.9，n = 18）。两组之间在代谢参数和胰岛素抵抗方面未观察到差异。这些参数与MAP的比较表明，唯一具有相关性的参数是BMI，与PCOS诊断无关。在夜间血压下降情况中未发现这种相关性，夜间血压下降与PCOS及任何其他研究参数均无关联。
与非PCOS女性相比，PCOS女性未表现出更高的动脉血压、血糖、高密度脂蛋白胆固醇（HDL - col）、甘油三酯（TG）、HOMA - IR和BMI。然而PCOS患者的动脉压与BMI之间存在相关性，提示肥胖是这些患者动脉压变化的主要因素。
