Foroozanfard Fatemeh, Soleimani Alireza, Arbab Elham, Samimi Mansooreh, Tamadon Mohammad Reza
Department of Gynecology and Obstetrics, Kashan University of Medical Sciences, Kashan, Iran.
Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran.
J Nephropathol. 2017 Jan;6(1):15-24. doi: 10.15171/jnp.2017.04. Epub 2016 Aug 8.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders with an inflammatory basis. It is associated with hyperandrogenism in women and can be also associated with increased activity of the renin-angiotensin system (RAS). Approximately 5% to 10% of women of reproductive age are affected by this disease. This syndrome is the main cause of infertility. Blood pressure may be one of the complications of the syndrome.
In this study, we sought to assess the role of the IL-17 inflammatory cytokine in increasing blood pressure in patients with PCOS.
In this cross-sectional study, after obtaining informed consent, we evaluated 85 patients with PCOS. IL-17 serum level was measured after separating the serum via ELISA method. The results obtained for the two groups of patients with high blood pressure and normal blood pressure were compared with each other.
The daytime blood pressure was abnormal in eight patients, while it was normal in 72 patients. The blood pressure during the day had a direct correlation with the IL-17serum level; as a result, the mean IL-17 serum level in patients with high blood pressure was 77.10 ± 17.94 ρ g/ml while in those with normal blood pressure it was 55.20 ± 13.71 ρ g/ml ( = 0.001). High blood pressure during the night also showed a direct relation with theIL-17 serum level ( = 0.001). In addition, increasing of ambulatory 24-hourblood pressure was significantly related with IL-17 serum level, in such a way that the IL-17 serum level of people with high blood pressure rose by almost 22 ρg/ml during 24 hours ( = 0.001).
Our results showed an association between PCO syndrome and inflammatory factors. The IL-17 serum level was directly associated with the increase in blood pressure.
多囊卵巢综合征（PCOS）是最常见的具有炎症基础的内分泌疾病之一。它与女性雄激素过多有关，也可能与肾素 - 血管紧张素系统（RAS）活性增加有关。大约5%至10%的育龄妇女受此疾病影响。该综合征是不孕症的主要原因。血压可能是该综合征的并发症之一。
在本研究中，我们试图评估白细胞介素 - 17（IL - 17）炎性细胞因子在PCOS患者血压升高过程中的作用。
在这项横断面研究中，获得知情同意后，我们评估了85例PCOS患者。通过酶联免疫吸附测定（ELISA）法分离血清后测量IL - 17血清水平。将高血压患者组和血压正常患者组的结果相互比较。
8例患者白天血压异常，72例患者白天血压正常。白天血压与IL - 17血清水平呈正相关；因此，高血压患者的平均IL - 17血清水平为77.10±17.94ρg/ml，而血压正常患者的平均IL - 17血清水平为55.20±13.71ρg/ml（P = 0.001）。夜间高血压也与IL - 17血清水平呈正相关（P = 0.001）。此外，动态24小时血压升高与IL - 17血清水平显著相关，以至于高血压患者的IL - 17血清水平在24小时内升高了近22ρg/ml（P = 0.001）。
我们的结果表明PCO综合征与炎症因子之间存在关联。IL - 17血清水平与血压升高直接相关。
