Clinic for Children’s Internal Diseases, Clinical Centre, University of Nis, 18000 Nis, Serbia.
Endokrynol Pol. 2012;63(6):414-9.
To evaluate the degree of atherosclerosis in children and adolescents with type 1 diabetes and its correlation with risk factors, traditional and other, such as anti-oxidative capacity of circulating blood and level of lipid peroxidation.
Forty children and adolescents with type 1 diabetes with mean age 13.7 years were compared with 20 age- and sex-matched healthy control subjects. Association of carotid artery intima-media thickness (cIMT) with different risk factors measured in children with type 1 diabetes was evaluated.
Mean carotid IMT was higher in subjects with diabetes (p 〈 0.01) and was strongly associated with total cholesterol with an odds ratio of 4.08 (p = 0.016), LDL-cholesterol with an odds ratio of 2.78 (p = 0.037), length of disease with an odds ratio of 1.87 (p = 0.007) and positive family history (first- and second-degree relatives) of diabetes and early CVD (heart attack and/or stroke before the age of 60 years) with an odds ratio of 6.8 (p = 0.007).
We found significantly increased cIMT in the diabetic patients compared to the healthy control subjects. Risk factors for the development of atherosclerosis included higher total and LDL-cholesterol, higher systolic blood pressure, positive family history of diabetes and early CVD and longer diabetes duration. In spite of the documented increased oxidative stress, we failed to establish a correlation between the oxidative stress parameters and cIMT values.
评估 1 型糖尿病儿童和青少年的动脉粥样硬化程度及其与传统和其他危险因素的相关性，如循环血液抗氧化能力和脂质过氧化水平。
将 40 名年龄在 13.7 岁的 1 型糖尿病患儿与 20 名年龄和性别匹配的健康对照组进行比较。评估 1 型糖尿病患儿不同危险因素与颈动脉内膜中层厚度（cIMT）的相关性。
糖尿病患者的平均颈动脉 IMT 较高（p 〈 0.01），与总胆固醇呈强相关，优势比为 4.08（p = 0.016），与 LDL-胆固醇呈强相关，优势比为 2.78（p = 0.037），与疾病长度呈强相关，优势比为 1.87（p = 0.007），与糖尿病和早发 CVD（60 岁前心脏病发作和/或中风）的一级和二级亲属阳性家族史呈强相关，优势比为 6.8（p = 0.007）。
与健康对照组相比，糖尿病患者的 cIMT 显著增加。动脉粥样硬化发展的危险因素包括总胆固醇和 LDL-胆固醇升高、收缩压升高、糖尿病和早发 CVD 的阳性家族史以及糖尿病病程较长。尽管有文献记载氧化应激增加，但我们未能确定氧化应激参数与 cIMT 值之间的相关性。
