慢性肾脏病氧化应激的临床和研究标志物。
Clinical and research markers of oxidative stress in chronic kidney disease.
机构信息
Clinical Biochemistry Laboratory, Institute for Health and Social Science Research, Central Queensland University, Rockhampton, QLD, Australia.
出版信息
Biomarkers. 2013 Mar;18(2):103-15. doi: 10.3109/1354750X.2012.749302. Epub 2013 Jan 23.
CONTEXT
Kidney-related pathologies have increasing prevalence rates, produce a considerable financial burden, and are characterized by elevated levels of oxidative stress (OS).
OBJECTIVE
This review examines relationships between chronic kidney disease (CKD) and markers of OS and antioxidant status (AS).
METHODS
A systematic review of MEDLINE-indexed clinical trials, randomized controlled trials and comparative studies that examined OS and AS was performed.
RESULTS AND CONCLUSION
Several markers emerged as well-suited indicators of OS and AS in CKD: malondialdehyde, F2-isoprostanes, lipid hydroperoxides, asymmetric dimethylarginine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, protein carbonyls, advanced oxidation protein products and glutathione-related activity.
背景
肾脏相关疾病的患病率不断上升，造成了巨大的经济负担，其特征是氧化应激（OS）水平升高。
目的
本综述研究了慢性肾脏病（CKD）与 OS 和抗氧化状态（AS）标志物之间的关系。
方法
对 MEDLINE 索引的临床试验、随机对照试验和比较研究进行了系统评价，以检查 OS 和 AS。
结果和结论
在 CKD 中，有几个标志物被认为是 OS 和 AS 的合适指标：丙二醛、F2-异前列腺素、脂质过氧化物、不对称二甲基精氨酸、8-氧代-7,8-二氢-2'-脱氧鸟苷、蛋白质羰基、高级氧化蛋白产物和谷胱甘肽相关活性。
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