Clinical Biochemistry Laboratory, Institute for Health and Social Science Research, Central Queensland University, Rockhampton, QLD, Australia.
Biomarkers. 2013 Mar;18(2):103-15. doi: 10.3109/1354750X.2012.749302. Epub 2013 Jan 23.
Kidney-related pathologies have increasing prevalence rates, produce a considerable financial burden, and are characterized by elevated levels of oxidative stress (OS).
This review examines relationships between chronic kidney disease (CKD) and markers of OS and antioxidant status (AS).
A systematic review of MEDLINE-indexed clinical trials, randomized controlled trials and comparative studies that examined OS and AS was performed.
Several markers emerged as well-suited indicators of OS and AS in CKD: malondialdehyde, F2-isoprostanes, lipid hydroperoxides, asymmetric dimethylarginine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, protein carbonyls, advanced oxidation protein products and glutathione-related activity.
肾脏相关疾病的患病率不断上升，造成了巨大的经济负担，其特征是氧化应激（OS）水平升高。
本综述研究了慢性肾脏病（CKD）与 OS 和抗氧化状态（AS）标志物之间的关系。
对 MEDLINE 索引的临床试验、随机对照试验和比较研究进行了系统评价，以检查 OS 和 AS。
在 CKD 中，有几个标志物被认为是 OS 和 AS 的合适指标：丙二醛、F2-异前列腺素、脂质过氧化物、不对称二甲基精氨酸、8-氧代-7,8-二氢-2'-脱氧鸟苷、蛋白质羰基、高级氧化蛋白产物和谷胱甘肽相关活性。
