Department of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, PR China.
Institute of Traditional Chinese Veterinary Medicine，Southwest University, Rongchang, Chongqing 402460, PR China.
Ecotoxicol Environ Saf. 2023 Nov 1;266:115606. doi: 10.1016/j.ecoenv.2023.115606. Epub 2023 Oct 21.
Oxidative stress (OS) constitutes a pivotal factor in the initiation and progression of lipopolysaccharide (LPS) challenges in broiler chickens. Increasing studies have demonstrated that Alleviation of oxidative stress seems to be a reasonable strategy to alleviate LPS-mediated afflictions in broilers. Nonetheless, the relationship between OS-related indicators and exposure to LPS remains a topic of debate. The aim of this investigation was to precisely and holistically evaluate the effect of LPS exposure on OS-associated markers. We conducted a systematic search of four electronic databases-PubMed, Web of Science, Scopus, and Cochrane for relevant studies, and a total of 31 studies were included. The overall results showed that the LPS treatment significantly increased the levels of oxygen radicals and their products, such as malondialdehydes (MDA), reactive oxygen species (ROS), and 8-hydroxy-2-deoxyguanosine (8-OHdG), while significantly reduced the levels of antioxidants, such as total antioxidative capacity (T-AOC), total superoxide dismutase (T-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione (GSH), in the chickens. Intriguingly, though the observed trends in alterations were not strictly correlated with LPS concentrations, the enzyme activity levels were indeed influenced by the concentration of LPS. This observation highlights the complex relationship between LPS exposure and the body's antioxidant response. Despite some limitations, all the included studies were deemed credible. Subgroup evaluations revealed that the jejunum and duodenum has demonstrated stronger antioxidant capability compared to other tissues. Overall, our study presents compelling evidence that exposure to LPS induces significant OS in chickens. And we also found that the extent of OS was related to LPS doses, target tissues, and dietary ingredients.
氧化应激（OS）是脂多糖（LPS）挑战引发和进展的关键因素。越来越多的研究表明，减轻氧化应激似乎是缓解 LPS 介导的肉鸡疾病的合理策略。然而，OS 相关指标与 LPS 暴露之间的关系仍然存在争议。本研究旨在精确和全面地评估 LPS 暴露对 OS 相关标志物的影响。我们对四个电子数据库——PubMed、Web of Science、Scopus 和 Cochrane 进行了系统检索，以查找相关研究，共纳入了 31 项研究。总体结果表明，LPS 处理显著增加了氧自由基及其产物的水平，如丙二醛（MDA）、活性氧（ROS）和 8-羟基-2-脱氧鸟苷（8-OHdG），而显著降低了抗氧化剂的水平，如总抗氧化能力（T-AOC）、总超氧化物歧化酶（T-SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）和谷胱甘肽（GSH）。有趣的是，尽管观察到的变化趋势与 LPS 浓度没有严格相关，但酶活性水平确实受到 LPS 浓度的影响。这一观察结果突出了 LPS 暴露与机体抗氧化反应之间的复杂关系。尽管存在一些局限性，但所有纳入的研究都被认为是可信的。亚组评估显示，空肠和十二指肠与其他组织相比表现出更强的抗氧化能力。总的来说，我们的研究提供了令人信服的证据，表明 LPS 暴露会导致鸡发生明显的 OS。我们还发现，OS 的程度与 LPS 剂量、靶组织和膳食成分有关。
