Montero-Vega M Teresa
Department of Research in Biochemistry, Ramon y Cajal Institute for Health Research (IRYCIS), Ramon y Cajal University Hospital, Ctra. Colmenar, km 9, 28034-Madrid, Spain.
Crit Rev Immunol. 2012;32(5):373-462. doi: 10.1615/critrevimmunol.v32.i5.10.
Atherosclerosis is considered an inflammatory disease that starts and evolves in response to cholesterol accumulation in the arterial intima of the large and medium arteries. In recent years, new insights into innate immunity have changed our understanding of the events that initiate and drive inflammation, changing many concepts about pathogenesis of inflammatory disorders and on the susceptibility to infections. This review summarizes some of the current concepts on innate immunity and rearranges old and new data on pathogenesis in atherosclerosis to shed light on the disease with a new inflammatory view.
动脉粥样硬化被认为是一种炎症性疾病，它始于并随着胆固醇在大中动脉内膜的积聚而发展。近年来，对固有免疫的新见解改变了我们对引发和驱动炎症事件的理解，改变了许多关于炎症性疾病发病机制和感染易感性的概念。这篇综述总结了一些关于固有免疫的当前概念，并重新整理了动脉粥样硬化发病机制的新旧数据，以从新的炎症视角阐明该疾病。
