Nakamura Yasuyuki, Ueshima Hirotsugu, Okuda Nagako, Miura Katsuyuki, Kita Yoshikuni, Okamura Tomonori, Okayama Akira, Choudhury Sohel R, Rodriguez Beatriz, Masaki Kamal H, Stamler Jeremiah
Cardiovascular Epidemiology, Kyoto Women's University, Kyoto 605-8501, Japan ; Department of Health Science, Shiga University of Medical Science, Otsu 520-2121, Japan.
Department of Health Science, Shiga University of Medical Science, Otsu 520-2121, Japan.
Int J Vasc Med. 2013;2013:601364. doi: 10.1155/2013/601364. Epub 2013 Nov 24.
Objective. Despite considerable study, the relevance of leptin and adiponectin for atherosclerosis development is still unsettled. We investigated relations of serum leptin and adiponectin to serum C-reactive protein (CRP), using the INTERLIPID dataset on Japanese emigrants living in Hawaii and Japanese in Japan. Design and Methods. Serum leptin, adiponectin, and CRP were measured by standardized methods in men and women of ages 40 to 59 years from two population samples, one Japanese-American in Hawaii (83 men, 89 women) and the other Japanese in central Japan (111 men, 104 women). Participants with CRP >10 mg/L were excluded. Results. Sex-specific multiple linear regression analyses, with log-transformed leptin and adiponectin (log-leptin, log-adipo), site (Hawaii = 1, Japan = 0), SBP, HbA1c, smoking (cigarettes/day), and physical activity index score of the Framingham Offspring Study as covariates, showed that log-leptin directly related and log-adipo inversely related to log-CRP for both sexes (Ps < 0.05 to <0.01). Addition to the model of BMI and interaction terms (BMI × log-leptin, BMI × log-adipo, SITE × log-leptin, SITE × log-adipo) resulted in disappearance of statistical significance except for direct relation of log-leptin to log-CRP in men (P = 0.006). Conclusions. Leptin directly related to CRP independent of BMI and other confounding factors in men but not in women.
目的。尽管进行了大量研究，但瘦素和脂联素与动脉粥样硬化发展的相关性仍未确定。我们使用了关于居住在夏威夷的日本移民和日本本土日本人的INTERLIPID数据集，研究血清瘦素和脂联素与血清C反应蛋白（CRP）之间的关系。设计与方法。通过标准化方法对来自两个样本群体、年龄在40至59岁之间的男性和女性进行血清瘦素、脂联素和CRP的测量，一个样本群体是夏威夷的日裔美国人（83名男性，89名女性），另一个样本群体是日本中部的日本人（111名男性，104名女性）。排除CRP>10mg/L的参与者。结果。以对数转换后的瘦素和脂联素（对数瘦素、对数脂联素）、地点（夏威夷=1，日本=0）、收缩压、糖化血红蛋白、吸烟量（每天吸烟支数）以及弗明汉后代研究的身体活动指数评分作为协变量进行性别特异性多元线性回归分析，结果显示，对数瘦素与对数CRP呈直接相关，对数脂联素与对数CRP呈负相关（P值在<0.05至<0.01之间）。在模型中加入BMI和交互项（BMI×对数瘦素、BMI×对数脂联素、地点×对数瘦素、地点×对数脂联素）后，除男性中对数瘦素与对数CRP的直接关系外（P = 0.006），统计显著性消失。结论。在男性中，瘦素与CRP直接相关，且不受BMI和其他混杂因素影响，但在女性中并非如此。
