成人苯丙酮尿症患者的精神症状。
Psychiatric symptoms in adults with phenylketonuria.
机构信息
Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
出版信息
Mol Genet Metab. 2013 Mar;108(3):155-60. doi: 10.1016/j.ymgme.2012.12.006. Epub 2012 Dec 31.
BACKGROUND
The objective of this study was to identify psychiatric symptom patterns reported by individuals with phenylketonuria (PKU) in the outpatient clinic setting.
METHODS
Brief Symptom Inventory (BSI) results, phenylalanine (phe) levels, and demographic information were collected through a retrospective chart review on 64 participants in the study, "A Diversified Approach for PKU Treatment" (ADAPT).
RESULTS
The number of BSI scores meeting clinical threshold was significantly elevated for all global indexes and 6 out of 7 symptom subscales in patients with PKU. Recent and mean phe levels were correlated with age at the time of screening (R(2)=0.10, R(2)=0.10, respectively; p<0.05). Psychoticism and the Positive Symptom Distress Index (PSDI) scores were associated with metabolic control.
CONCLUSIONS
The results of this study demonstrate a positive correlation between phe levels and psychiatric symptom severity in individuals with PKU.
背景
本研究的目的是确定在门诊环境中报告的苯丙酮尿症（PKU）个体的精神症状模式。
方法
通过对研究“PKU 治疗的多样化方法”（ADAPT）中的 64 名参与者的回顾性图表审查，收集了简短症状清单（BSI）结果、苯丙氨酸（phe）水平和人口统计学信息。
结果
PKU 患者的所有总体指标和 7 个症状子量表中的 6 个的 BSI 评分达到临床阈值的数量显著升高。最近和平均 phe 水平与筛查时的年龄呈正相关（R²=0.10，R²=0.10；p<0.05）。精神病和阳性症状困扰指数（PSDI）得分与代谢控制有关。
结论
这项研究的结果表明，PKU 个体的 phe 水平与精神症状严重程度之间存在正相关。
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