Ilsong Institute of Life Science, Hallym University, Anyang, Gyeonggi-do 431-060, Republic of Korea.
Burns. 2013 Sep;39(6):1200-5. doi: 10.1016/j.burns.2012.12.013. Epub 2013 Jan 20.
Approximately 8% of the human genome is composed of retroviral sequences, which are known as human endogenous retroviruses (HERVs) and, have been implicated in both health status and disease. Recently, indirect evidence for a possible role of retroviral elements in the systemic response to stress signals has been provided by several studies. In the present study, we sought to evaluate the relationship between HERVs and major burn in humans.
We investigated the prevalence of HERV families by reverse transcriptase PCR (RT-PCR) in cell-free plasma samples from patients with burns and from normal individuals.
Different prevalences of HERV families were observed in the plasma samples from the burn patient group and normal group. Compared with the prevalences of HERV-W and HERV-K in the normal group, in the burn patient group, the prevalence of HERV-W was significantly lower (P<0.001), but the prevalence of HERV-K was higher (P=0.059).
Our study of the prevalences of HERVs revealed that the activation of certain HERV families may be influenced not only by burns but also by the initial treatments that were used to address these injuries.
人类基因组的大约 8%由逆转录病毒序列组成，这些序列被称为人类内源性逆转录病毒（HERV），并与健康状况和疾病都有关联。最近，几项研究提供了间接证据，表明逆转录病毒元件可能在应激信号的全身反应中起作用。在本研究中，我们试图评估 HERV 与人类大面积烧伤之间的关系。
我们通过逆转录酶聚合酶链反应（RT-PCR）检测了来自烧伤患者和正常个体的无细胞血浆样本中 HERV 家族的流行情况。
烧伤患者组和正常组的血浆样本中观察到 HERV 家族的不同流行率。与正常组相比，HERV-W 在烧伤患者组中的流行率显著降低（P<0.001），而 HERV-K 的流行率较高（P=0.059）。
我们对 HERV 流行率的研究表明，某些 HERV 家族的激活不仅可能受到烧伤的影响，还可能受到用于处理这些损伤的初始治疗的影响。
