Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.
Diabetes Care. 2013 Jul;36(7):1974-80. doi: 10.2337/dc12-1893. Epub 2013 Jan 22.
Prolactin is a major stimulus for the β-cell adaptation during gestation and guards postpartum women against gestational diabetes. Most studies of the role of prolactin on glucose metabolism have been conducted in humans and animals during pregnancy. However, little is known concerning the association between circulating prolactin and glucose metabolism outside pregnancy in epidemiological studies. We aimed to determine whether the variation of circulating prolactin concentration associates with diabetes and impaired glucose regulation (IGR) in a cross-sectional study.
We recruited 2,377 participants (1,034 men and 1,343 postmenopausal women) without hyperprolactinemia, aged 40 years and older, in Shanghai, China. Diabetes and IGR were determined by an oral glucose tolerance test. Multinomial logit analyses were performed to evaluate the relationship of prolactin with diabetes and IGR.
Prolactin levels decreased from normal glucose regulation to IGR to diabetes. Multinomial logit analyses, adjusted for potential confounding factors, showed that high circulating prolactin was associated with lower prevalence of diabetes and IGR. The adjusted odds ratios (95% CI) for IGR and diabetes for the highest compared with the lowest quartile of prolactin were 0.54 (95% CI 0.33-0.89) and 0.38 (0.24-0.59) in men and 0.54 (0.36-0.81) and 0.47 (0.32-0.70) in women.
High circulating prolactin associates with lower prevalence of diabetes and IGR in the current study. Further studies are warranted to confirm this association.
催乳素是妊娠期间β细胞适应的主要刺激因素，并能保护产后妇女免受妊娠糖尿病的影响。大多数关于催乳素对葡萄糖代谢作用的研究都是在人类和动物怀孕期间进行的。然而，在流行病学研究中，关于循环催乳素与妊娠外葡萄糖代谢之间的关联知之甚少。我们旨在确定在一项横断面研究中，循环催乳素浓度的变化是否与糖尿病和葡萄糖调节受损（IGR）相关。
我们在中国上海招募了 2377 名年龄在 40 岁及以上、无高催乳素血症的参与者（1034 名男性和 1343 名绝经后女性）。糖尿病和 IGR 通过口服葡萄糖耐量试验确定。采用多项逻辑回归分析评估催乳素与糖尿病和 IGR 的关系。
催乳素水平从正常葡萄糖调节到 IGR 再到糖尿病逐渐降低。经潜在混杂因素调整的多项逻辑回归分析显示，高循环催乳素与糖尿病和 IGR 的患病率降低相关。与催乳素最低四分位相比，催乳素最高四分位的 IGR 和糖尿病的调整比值比（95%CI）分别为 0.54（95%CI 0.33-0.89）和 0.38（0.24-0.59），在男性中分别为 0.54（95%CI 0.36-0.81）和 0.47（0.32-0.70）。
在本研究中，高循环催乳素与糖尿病和 IGR 的患病率降低相关。需要进一步的研究来证实这种关联。
