Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Diabetes Care. 2018 Mar;41(3):440-445. doi: 10.2337/dc17-1570. Epub 2017 Dec 20.
To examine the association of plasma alkylresorcinol metabolite 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, with type 2 diabetes (T2D) and impaired glucose regulation (IGR) in a Chinese population.
A total of 1,060 newly diagnosed T2D patients, 736 newly diagnosed IGR patients, and 1,443 control subjects with normal glucose tolerance were recruited in the case-control study. Plasma DHPPA concentrations were determined by high-performance liquid chromatography-tandem mass spectroscopy. Multivariate logistic regression analysis was used to evaluate the independent association of plasma DHPPA concentrations with the likelihood of T2D and IGR.
After adjustment for age, sex, BMI, and family history of diabetes, the odds ratios (95% CI) of T2D and IGR were 0.57 (0.45, 0.73) and 0.66 (0.50, 0.85), respectively, comparing the lowest with the highest quartile of plasma DHPPA concentrations. Further adjustment for current smoking status, current alcohol consumption, physical activity, history of hypertension, and educational level did not change the observed association materially. Similar results were also obtained in T2D and IGR groups combined. The inverse association of plasma DHPPA with T2D persisted in stratified analyses according to age, sex, BMI, current smoking status, current alcohol consumption, physical activity, family history of diabetes, and history of hypertension.
These findings suggested that higher plasma DHPPA concentrations were associated with lower odds of T2D and IGR. Further studies are warranted to confirm these findings in prospective cohorts.
研究血浆烷基间苯二酚代谢物 3-(3,5-二羟基苯基）-1-丙酸（DHPPA）与 2 型糖尿病（T2D）和葡萄糖调节受损（IGR）的相关性，该标志物可反映全谷物小麦和黑麦的摄入量。
本病例对照研究共纳入 1060 例新诊断的 T2D 患者、736 例新诊断的 IGR 患者和 1443 例血糖正常的对照者。采用高效液相色谱-串联质谱法测定血浆 DHPPA 浓度。采用多变量 logistic 回归分析评估血浆 DHPPA 浓度与 T2D 和 IGR 发生几率的独立相关性。
在校正年龄、性别、BMI 和糖尿病家族史后，与血浆 DHPPA 浓度最低四分位数相比，最高四分位数患者发生 T2D 和 IGR 的比值比（95%CI）分别为 0.57（0.45，0.73）和 0.66（0.50，0.85）。进一步校正当前吸烟状况、当前饮酒、身体活动、高血压史和受教育程度，并未明显改变观察到的相关性。在 T2D 和 IGR 患者合并组中也得到了类似的结果。根据年龄、性别、BMI、当前吸烟状况、当前饮酒、身体活动、糖尿病家族史和高血压史进行分层分析时，DHPPA 与 T2D 的负相关关系仍然存在。
这些发现表明，较高的血浆 DHPPA 浓度与 T2D 和 IGR 的发生几率较低相关。需要进一步的研究来在前瞻性队列中证实这些发现。
