Department of Hepatobiliary Surgery, Xinqiao Hospital, Third Military Medical University, 400037, NO.2 Xin Qiao Street, Sha Ping Ba District, Chongqing, People's Republic of China.
Pathol Oncol Res. 2013 Apr;19(2):251-8. doi: 10.1007/s12253-012-9576-y. Epub 2013 Jan 23.
In our study, we used the GSE17967 series to identify differentially expressed genes between cirrhosis and hepatocellular carcinoma, aiming to analyse the mechanism of the progression of cirrhosis to hepatocellular carcinoma and identify the sub-pathways closely related to this progression, and find the small molecule drugs to interfere this progression. From the result of our study, we find that many small molecule drugs closely related with carcinoma have been linked by our method. We also find some new small molecule drugs related to this progression. It is demonstrated that bioinformatics analysis is useful in identification of the candidate drugs in hepatocellular carcinoma.
在我们的研究中,我们使用了 GSE17967 系列来鉴定肝硬化和肝细胞癌之间差异表达的基因,旨在分析肝硬化向肝细胞癌进展的机制,并确定与该进展密切相关的亚途径,找到小分子药物来干扰这一进展。从我们的研究结果中,我们发现我们的方法已经将许多与癌密切相关的小分子药物联系起来。我们还发现了一些与这一进展相关的新的小分子药物。这表明生物信息学分析在鉴定肝细胞癌的候选药物方面是有用的。