Giai M, Natoli C, Sismondi P, Biglia N, Lesti G, Mulieri M, Iacobelli S
Cattedra di Oncologia Medica, Università G. D'Annunzio, Chieti, Italy.
Anticancer Res. 1990 Jan-Feb;10(1):119-21.
One major problem in primary breast cancer is the identification of new parameters able to select patients at high risk of recurrence. Our study was aimed at detecting mammary tumor cells in the bone marrow of breast cancer patients using a single bone marrow sampling and the monoclonal antibody AB/3. This antibody recognizes a membrane carbohydrate epitope present in human breast cancer cells but not in normal tissues. Only 2 out of 45 breast cancer patients were found to have a bone marrow positive AB/3 staining reaction. Our data confirm and extend previous reports that single bone marrow sampling coupled with immunocytochemistry is not sensitive enough to be used as a routine procedure to acquire prognostic information in breast cancer.
原发性乳腺癌的一个主要问题是识别能够筛选出高复发风险患者的新参数。我们的研究旨在通过单次骨髓采样和单克隆抗体AB/3检测乳腺癌患者骨髓中的乳腺肿瘤细胞。该抗体识别存在于人类乳腺癌细胞而非正常组织中的一种膜碳水化合物表位。45例乳腺癌患者中仅2例骨髓AB/3染色反应呈阳性。我们的数据证实并拓展了先前的报道，即单次骨髓采样联合免疫细胞化学作为获取乳腺癌预后信息的常规方法，敏感性不足。
