子宫内膜癌中的雌激素与临床特征
Oestrogens and clinical characteristics in endometrial carcinoma.
作者信息
Boman K, Bäckström T, Gerdes U, Stendahl U
机构信息
Department of Gynaecological Oncology, University of Umeå, Sweden.
出版信息
Anticancer Res. 1990 Jan-Feb;10(1):247-51.
Serum concentrations of endogenously produced oestrogens were studied in 128 postmenopausal women with endometrial carcinoma. Radioimmunoassays of serum oestrone (E1) and oestradiol (E2) were performed on admission to hospital. Results showed a wide variation in serum concentrations of E1 and E2 in patients with endometrial carcinoma. Some patients had high E1 values and low E2, while none of the patients had low E1 and high E2 values. Hormonal levels were correlated with increasing BMI (E1; p less than 0.000001; E2; p less than 0.000001). Uterine cavity depth was also related to both E1 and E2 (E1; p less than 0.00001; E2; p less than 0.0003). Concentrations of E1 and E2 were higher in diabetic women than in the non-diabetic. (E1; p less than 0.002; E2; p less than 0.01). E2 concentration was higher in hypertensive patients than in the non-hypertensive patients (p less than 0.04). Parameters such as age, menstrual history, clinical stage and histopathology showed no significant correlation with hormone concentrations.
对128例子宫内膜癌绝经后妇女内源性雌激素的血清浓度进行了研究。入院时对血清雌酮（E1）和雌二醇（E2）进行了放射免疫测定。结果显示，子宫内膜癌患者血清E1和E2浓度差异很大。一些患者E1值高而E2值低，而没有患者E1值低而E2值高。激素水平与体重指数增加相关（E1；p<0.000001；E2；p<0.000001）。子宫腔深度也与E1和E2相关（E1；p<0.00001；E2；p<0.0003）。糖尿病女性的E1和E2浓度高于非糖尿病女性。（E1；p<0.002；E2；p<0.01）。高血压患者的E2浓度高于非高血压患者（p<0.04）。年龄、月经史、临床分期和组织病理学等参数与激素浓度无显著相关性。
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