Törnberg S A, Carstensen J M
Department of General Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Br J Cancer. 1994 Feb;69(2):358-61. doi: 10.1038/bjc.1994.65.
The relationship between Quetelet's index and subsequent risk for cancer of endocrine target organs was studied in a cohort of 47,003 women, examined for height and weight in the years 1963-65, and followed up in the Swedish Cancer Register until 1987. High Quetelet's index was associated with a decreased risk for breast cancer among women less than 55 years of age at risk, while a high Quetelet's index predicted an increased risk among older women. Among women > or = 55 years of age, the excess relative risk for breast cancer associated with high Quetelet's index declined significantly during the follow-up period. Cancer of the ovaries and the uterine cervix were not significantly related to Quetelet's index in any age group. In women > or = 55 years of age, the relative risk for cancer of the uterine corpus associated to Quetelet's index was higher than that for breast cancer, and this association persisted during the entire follow-up period of more than 20 years. In spite of the fact that endometrial cancer is less common than breast cancer, because of the stronger relation between overweight and endometrial cancer, more endometrial cancer would be attributable to obesity than breast cancer.
在一个由47003名女性组成的队列中，研究了奎特利指数与后续内分泌靶器官癌症风险之间的关系。这些女性在1963年至1965年期间接受了身高和体重检查，并在瑞典癌症登记处随访至1987年。在处于风险中的55岁以下女性中，高奎特利指数与乳腺癌风险降低相关，而高奎特利指数在老年女性中则预示着风险增加。在年龄≥55岁的女性中，与高奎特利指数相关的乳腺癌超额相对风险在随访期间显著下降。卵巢癌和宫颈癌在任何年龄组中与奎特利指数均无显著相关性。在年龄≥55岁的女性中，与奎特利指数相关的子宫体癌相对风险高于乳腺癌，且这种关联在超过20年的整个随访期间持续存在。尽管子宫内膜癌不如乳腺癌常见，但由于超重与子宫内膜癌之间的关系更强，肥胖导致的子宫内膜癌比乳腺癌更多。
