Ogasawara H, Kurisu K, Mikami T, Hotta T, Sugiyama K, Kiya K, Uozumi T
Dept. of Neurosurgery, Hiroshima University School of Medicine.
Gan To Kagaku Ryoho. 1990 May;17(5):1033-8.
Etoposide delivery to 9L gliosarcoma model in Fischer 344 rats was evaluated. Etoposide 2 mg/body was given intravenously (IV) or intracarotidly with (IHIC) or without (IC) intravenously administrated angiotensin II. Mean etoposide concentration of tumors was 5.08 micrograms/g for IHIC group, 2.27 micrograms/g for IC group and 0.70 micrograms/g for IV group. The difference in etoposide concentration between IHIC group and IV group was statistically significant (p less than 0.05). In addition, etoposide concentrations of the normal brain tissues were lower than concurrent plasma concentrations in all groups. The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II. These studies might suggest that intraarterial chemotherapy by induced hypertension with angiotensin II was useful on treatment of malignant brain tumors.
对Fischer 344大鼠的9L胶质肉瘤模型进行了依托泊苷给药评估。依托泊苷2mg/只，通过静脉内（IV）或颈内动脉给药，静脉内给予血管紧张素II（IHIC）或不给予（IC）。IHIC组肿瘤的依托泊苷平均浓度为5.08微克/克，IC组为2.27微克/克，IV组为0.70微克/克。IHIC组和IV组之间依托泊苷浓度的差异具有统计学意义（p小于0.05）。此外，所有组中正常脑组织的依托泊苷浓度均低于同期血浆浓度。在Fischer 344大鼠的9L胶质肉瘤中，通过血管紧张素II诱导高血压，肿瘤中的依托泊苷浓度升高，而正常脑组织中的浓度非常低。这些研究可能表明，通过血管紧张素II诱导高血压进行动脉内化疗对恶性脑肿瘤的治疗是有用的。
