甲状腺功能亢进症中炎症与心房颤动的关系。
Association of inflammation with atrial fibrillation in hyperthyroidism.
机构信息
Department of Cardiology, Suleyman Demirel University, Kurtulus Mah 122. cad. Hatice Halici apt. no: 126, 32040 Isparta, Turkey.
出版信息
J Geriatr Cardiol. 2012 Dec;9(4):344-8. doi: 10.3724/SP.J.1263.2012.06251.
OBJECTIVES
The aim of this study was to evaluate the relationship between inflammation and development of atrial fibrillation (AF) in patients with hyperthyroidism.
METHODS
A total of 65 patients with newly diagnosed hyperthyroidism, 35 of whom were in sinus rhythm and 30 of whom in AF. Thirty five age- and gender-matched patients in a control group were included in the study. Factors associated with the development of AF were evaluated by multivariate regression analysis.
RESULTS
FACTORS ASSOCIATED WITH AF IN MULTIVARIATE ANALYSIS INCLUDED HIGH SENSITIVITY C REACTIVE PROTEIN (HSCRP) [ODDS RATIO (OR): 11.19; 95% confidence interval (95% CI): 1.80-69.53; P = 0.003], free T4 (OR: 8.76; 95% CI: 2.09-36.7; P = 0.003), and left atrial diameter (OR: 1.25; 95% CI: 1.06-1.47; P = 0.008).
CONCLUSIONS
The results of the present study suggest that HsCRP, an indicator of inflammation, free T4 and left atrial diameter are associated with the development AF in patients with hyperthyroidism.
目的
本研究旨在评估甲状腺功能亢进患者炎症与心房颤动（AF）发展之间的关系。
方法
共纳入 65 例新诊断为甲状腺功能亢进症的患者，其中 35 例为窦性心律，30 例为 AF。研究纳入了 35 名年龄和性别匹配的对照组患者。通过多变量回归分析评估与 AF 发展相关的因素。
结果
多变量分析中与 AF 相关的因素包括高敏 C 反应蛋白（hsCRP）[优势比（OR）：11.19；95%置信区间（95%CI）：1.80-69.53；P=0.003]、游离 T4（OR：8.76；95%CI：2.09-36.7；P=0.003）和左心房直径（OR：1.25；95%CI：1.06-1.47；P=0.008）。
结论
本研究结果表明，hsCRP 作为炎症的指标、游离 T4 和左心房直径与甲状腺功能亢进症患者 AF 的发展有关。
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