高密度脂蛋白与动脉粥样硬化：新视角。
High density lipoproteins and atherosclerosis: emerging aspects.
机构信息
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy.
出版信息
J Geriatr Cardiol. 2012 Dec;9(4):401-7. doi: 10.3724/SP.J.1263.2011.12282.
Abstract
High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.
摘要
高密度脂蛋白（HDL）促进外周组织中多余胆固醇向肝脏排出。这种能力是 HDL 最相关的抗动脉粥样硬化作用的原因。HDL 促进胆固醇流出的能力还导致参与动脉粥样硬化的免疫细胞中一系列反应的调节，包括单核细胞-巨噬细胞、B 和 T 淋巴细胞。此外，在炎症期间，这类脂蛋白的组成在很大程度上发生变化，从而促进了功能失调的 HDL 的形成。本综述的目的是讨论 HDL 在动脉粥样形成过程中调节免疫细胞和免疫炎症介质活性的新作用。
相似文献
1
High density lipoproteins and atherosclerosis: emerging aspects.
J Geriatr Cardiol. 2012 Dec;9(4):401-7. doi: 10.3724/SP.J.1263.2011.12282.
2
HDLs, immunity, and atherosclerosis.
Curr Opin Lipidol. 2011 Oct;22(5):410-6. doi: 10.1097/MOL.0b013e32834adac3.
3
Emerging role of high density lipoproteins as a player in the immune system.
Atherosclerosis. 2012 Jan;220(1):11-21. doi: 10.1016/j.atherosclerosis.2011.06.045. Epub 2011 Jul 2.
4
Dysfunctional High-Density Lipoproteins Are Associated With a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk: A Nested Case-Control Study.
Circulation. 2020 Feb 11;141(6):444-453. doi: 10.1161/CIRCULATIONAHA.119.041658. Epub 2020 Jan 16.
5
[Dysfunctional High-Density Lipoproteins: Role in Atherogenesis and Potential Targets for Phospholipid Therapy].
Kardiologiia. 2018 Mar(3):73-83.
6
High density lipoprotein biogenesis, cholesterol efflux, and immune cell function.
Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2561-5. doi: 10.1161/ATVBAHA.112.300135.
7
High-density lipoprotein: antioxidant and anti-inflammatory properties.
Curr Atheroscler Rep. 2007 Sep;9(3):244-8. doi: 10.1007/s11883-007-0026-3.
8
ATP-binding cassette transporters A1 and G1, HDL metabolism, cholesterol efflux, and inflammation: important targets for the treatment of atherosclerosis.
Curr Drug Targets. 2011 May;12(5):647-60. doi: 10.2174/138945011795378522.
9
Apolipoprotein A-I but not high-density lipoproteins are internalised by RAW macrophages: roles of ATP-binding cassette transporter A1 and scavenger receptor BI.
J Mol Med (Berl). 2008 Feb;86(2):171-83. doi: 10.1007/s00109-007-0267-1. Epub 2007 Oct 1.
10
High-density lipoproteins from probucol-treated patients have increased capacity to promote cholesterol efflux from mouse peritoneal macrophages loaded with acetylated low-density lipoproteins.
Eur J Clin Invest. 1997 Apr;27(4):285-92. doi: 10.1046/j.1365-2362.1997.1040657.x.
引用本文的文献
1
Association between cardiometabolic risk factors and COVID-19 susceptibility, severity and mortality: a review.
J Diabetes Metab Disord. 2021 Jun 26;20(2):1743-1765. doi: 10.1007/s40200-021-00822-2. eCollection 2021 Dec.
2
HDL in Immune-Inflammatory Responses: Implications beyond Cardiovascular Diseases.
Cells. 2021 Apr 29;10(5):1061. doi: 10.3390/cells10051061.
3
The Atherogenic Role of Circulating Modified Lipids in Atherosclerosis.
Int J Mol Sci. 2019 Jul 20;20(14):3561. doi: 10.3390/ijms20143561.
4
Lipoprotein Heterogeneity Early in Pregnancy and Preterm Birth.
Am J Perinatol. 2017 Nov;34(13):1326-1332. doi: 10.1055/s-0037-1603471. Epub 2017 May 22.
5
Why are kids with lupus at an increased risk of cardiovascular disease?
Pediatr Nephrol. 2016 Jun;31(6):861-83. doi: 10.1007/s00467-015-3202-7. Epub 2015 Sep 23.
6
The prevention and treatment effects of egg yolk high density lipoprotein on the formation of atherosclerosis plaque in rabbits.
Iran J Basic Med Sci. 2015 Apr;18(4):343-9.
7
High density lipoprotein promotes proliferation of adipose-derived stem cells via S1P1 receptor and Akt, ERK1/2 signal pathways.
Stem Cell Res Ther. 2015 May 15;6(1):95. doi: 10.1186/s13287-015-0090-5.
8
HDL: to treat or not to treat?
Curr Atheroscler Rep. 2014 Aug;16(8):429. doi: 10.1007/s11883-014-0429-x.
9
Nonesterified fatty acids and spontaneous preterm birth: a factor analysis for identification of risk patterns.
Am J Epidemiol. 2014 May 15;179(10):1208-15. doi: 10.1093/aje/kwu037. Epub 2014 Apr 8.
10
The roles of genetic polymorphisms and human immunodeficiency virus infection in lipid metabolism.
Biomed Res Int. 2013;2013:836790. doi: 10.1155/2013/836790. Epub 2013 Nov 12.
本文引用的文献
1
HDLs, immunity, and atherosclerosis.
Curr Opin Lipidol. 2011 Oct;22(5):410-6. doi: 10.1097/MOL.0b013e32834adac3.
2
Emerging role of high density lipoproteins as a player in the immune system.
Atherosclerosis. 2012 Jan;220(1):11-21. doi: 10.1016/j.atherosclerosis.2011.06.045. Epub 2011 Jul 2.
3
The immune system in atherosclerosis.
Nat Immunol. 2011 Mar;12(3):204-12. doi: 10.1038/ni.2001.
4
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.
N Engl J Med. 2011 Jan 13;364(2):127-35. doi: 10.1056/NEJMoa1001689.
5
The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.
Nat Immunol. 2010 Nov;11(11):1047-56. doi: 10.1038/ni.1939. Epub 2010 Sep 19.
6
Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-/-, ApoA-I-/- mice.
J Biol Chem. 2010 Nov 12;285(46):36158-69. doi: 10.1074/jbc.M110.134130. Epub 2010 Sep 10.
7
The long pentraxin PTX3: a modulator of the immunoinflammatory response in atherosclerosis and cardiovascular diseases.
Trends Cardiovasc Med. 2010 Feb;20(2):35-40. doi: 10.1016/j.tcm.2010.03.005.
8
Medicine. Tackling two diseases with HDL.
Science. 2010 Jun 25;328(5986):1641-2. doi: 10.1126/science.1191663.
9
Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis.
Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1832-41. doi: 10.1161/ATVBAHA.110.206813. Epub 2010 Jun 10.
10
ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation.
Science. 2010 Jun 25;328(5986):1689-93. doi: 10.1126/science.1189731. Epub 2010 May 20.
Zotero 插件