高密度脂蛋白与动脉粥样硬化：新视角。
High density lipoproteins and atherosclerosis: emerging aspects.
机构信息
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy.
出版信息
J Geriatr Cardiol. 2012 Dec;9(4):401-7. doi: 10.3724/SP.J.1263.2011.12282.
Abstract
High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.
摘要
高密度脂蛋白（HDL）促进外周组织中多余胆固醇向肝脏排出。这种能力是 HDL 最相关的抗动脉粥样硬化作用的原因。HDL 促进胆固醇流出的能力还导致参与动脉粥样硬化的免疫细胞中一系列反应的调节，包括单核细胞-巨噬细胞、B 和 T 淋巴细胞。此外，在炎症期间，这类脂蛋白的组成在很大程度上发生变化，从而促进了功能失调的 HDL 的形成。本综述的目的是讨论 HDL 在动脉粥样形成过程中调节免疫细胞和免疫炎症介质活性的新作用。
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