Department of Internal Medicine, Section of Rheumatology, LSU Health Sciences Center at New Orleans, New Orleans, LA, USA.
Ther Adv Chronic Dis. 2012 Nov;3(6):259-69. doi: 10.1177/2040622312459673.
Psoriatic arthritis is a common systemic inflammatory disorder, which in addition to skin and nail involvement may be associated with peripheral and axial joint involvement, enthesitis, dactylitis, and important comorbidities - especially cardiovascular morbidity. Better insights into the involved pathogenic mechanisms have resulted in an improved therapeutic armamentarium, which targets key pathways in its pathogenesis. This has resulted in significant clinical responses to newer therapeutic agents, especially those directed at inhibition of tumor necrosis factor α. Biological therapy leads to significant levels of remission, improved quality of life, and retards or improves structural radiological damage.
银屑病关节炎是一种常见的系统性炎症性疾病，除皮肤和指甲受累外，还可能与外周和中轴关节受累、肌腱端炎、指（趾）炎和重要的合并症（特别是心血管发病率）相关。对相关发病机制的深入了解导致了治疗手段的改进，这些手段针对其发病机制中的关键途径。这导致对新型治疗药物的显著临床反应，尤其是那些针对肿瘤坏死因子 α 抑制的药物。生物治疗可达到显著的缓解水平，提高生活质量，并延缓或改善结构影像学损伤。
