Yoon Young Kwon, Kim Ae Ryoung, Kim On Yoo, Lee Kilchan, Suh Young Joo, Cho Sung-Rae
Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea.
Ann Rehabil Med. 2012 Dec;36(6):770-5. doi: 10.5535/arm.2012.36.6.770. Epub 2012 Dec 28.
To clarify factors affecting bone mineral density (BMD) in adults with cerebral palsy (CP).
Thirty-five patients with CP participated in this study. Demographic data including gender, age, body mass index (BMI), subtype according to neuromotor type and topographical distribution, ambulatory function, and functional independence measure (FIM) were investigated. The BMD of the lumbar spine and femur were measured using Dual-energy X-ray absorptiometry, and the factors affecting BMD were analyzed.
The BMD had no significant association with factors such as gender, age, and subtype in adults with CP. However, BMI was significantly correlated with the BMD of lumbar spine and femur (p<0.05). The FIM score was also positively correlated with the BMD of femur (p<0.05). Moreover, CP patients with higher ambulatory function had significantly higher BMD of femur (p<0.05).
These findings suggest that BMI and functional levels such as FIM and ambulatory function can affect BMD in adults with CP. The results might be used as basic data, suggesting the importance of treatment including weight bearing exercise and gait training in adults with CP.
阐明影响成人脑瘫(CP)患者骨密度(BMD)的因素。
35例CP患者参与本研究。调查了人口统计学数据,包括性别、年龄、体重指数(BMI)、根据神经运动类型和地形分布的亚型、步行功能以及功能独立性测量(FIM)。使用双能X线吸收法测量腰椎和股骨的骨密度,并分析影响骨密度的因素。
在成人CP患者中,骨密度与性别、年龄和亚型等因素无显著关联。然而,BMI与腰椎和股骨的骨密度显著相关(p<0.05)。FIM评分也与股骨的骨密度呈正相关(p<0.05)。此外,步行功能较高的CP患者股骨骨密度显著更高(p<0.05)。
这些发现表明,BMI以及FIM和步行功能等功能水平可影响成人CP患者的骨密度。这些结果可作为基础数据,提示负重运动和步态训练等治疗在成人CP患者中的重要性。