Furlan N F, Gavião M B D, Barbosa T S, Nicolau J, Castelo P M
Piracicaba Dental School, State University of Campinas, Piracicaba.
J Clin Pediatr Dent. 2012 Fall;37(1):83-7. doi: 10.17796/jcpd.37.1.n32m21n08417v363.
Anxiety and stress are usually related to the dental treatment situation. The objective was to investigate salivary cortisol and alpha-amylase levels (salivary biomarkers) and heart rate in children undergoing a minor dental procedure (dental prophylaxis).
In total, 31 children (range 84-95 months) of both genders without caries or history of dental treatment/pain/trauma were selected. Three saliva samples were gathered: one prior to dental prophylaxis, one immediately after and one ten minutes later. Weight and height were assessed, and heart rate was evaluated prior to and during the procedure. Data were analyzed by correlation tests and t-test/Wilcoxon (alpha = 0.05).
Higher cortisol and amylase levels were observed before prophylaxis compared to afterward. Cortisol and amylase levels did not show a significant correlation, nor did salivary biomarkers and body mass index. However, heart rate and amylase levels showed a significant positive correlation.
In the studied sample, certain anticipation of the dental treatment was observed because higher cortisol and amylase levels were observed before, rather than after the event; moreover a significant correlation between amylase levels and heart rate was observed Thus, salivary biomarkers may be a valuable tool for evaluating anxiety-producing events, such as dental treatment, in children.
焦虑和压力通常与牙科治疗情况相关。本研究旨在调查接受小型牙科治疗（牙齿预防性治疗）的儿童的唾液皮质醇和α-淀粉酶水平（唾液生物标志物）以及心率。
总共选取了31名年龄在84至95个月之间、无龋齿且无牙科治疗/疼痛/创伤史的儿童，男女不限。采集了三份唾液样本：一份在牙齿预防性治疗前，一份在治疗后立即采集，另一份在十分钟后采集。评估了体重和身高，并在治疗前和治疗过程中评估了心率。通过相关性检验和t检验/威尔科克森检验（α = 0.05）对数据进行分析。
与治疗后相比，治疗前观察到更高的皮质醇和淀粉酶水平。皮质醇和淀粉酶水平未显示出显著相关性，唾液生物标志物与体重指数之间也未显示出显著相关性。然而，心率与淀粉酶水平显示出显著的正相关。
在本研究样本中，观察到对牙科治疗存在一定的预期，因为在治疗前而非治疗后观察到更高的皮质醇和淀粉酶水平；此外，还观察到淀粉酶水平与心率之间存在显著相关性。因此，唾液生物标志物可能是评估儿童牙科治疗等焦虑诱发事件的有价值工具。
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