Mrabet D, Selmi A, Filali A, Sahli H, Sellami S
Service de Rhumatologie, CHU La Rabta, 1007 Tunis, Tunisie.
Rev Med Liege. 2012 Dec;67(12):619-22.
A 27-year-old-man was diagnosed as having ankylosing spondylitis (AS) in 2003 and received a treatment by etanercept. Typical symptoms of active Crohn's disease (CD) developed 11 months after initiation of etanercept therapy. At colonoscopy, lesions compatible with CD were found endoscopically and histologically. Etanercept was interrupted and CD responded to standard treatment. A switch to infliximab was decided to treat a flare up ofAS. New onset CD may be considered an immune mediated injury induced by etanercept, but the causative role of the latter has not been demonstrated at this stage.
一名27岁男性于2003年被诊断为强直性脊柱炎（AS），并接受了依那西普治疗。在依那西普治疗开始11个月后出现了活动性克罗恩病（CD）的典型症状。结肠镜检查时，在内镜和组织学上均发现了与CD相符的病变。依那西普治疗中断，CD对标准治疗有反应。决定换用英夫利昔单抗来治疗AS的发作。新发CD可能被认为是依那西普诱导的免疫介导损伤，但在现阶段后者的致病作用尚未得到证实。
