Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China.
J Diabetes. 2013 Sep;5(3):275-81. doi: 10.1111/1753-0407.12028. Epub 2013 May 28.
Genetic variants of PPP1R3B, a gene encoding a critical protein involved in hepatic glycogen metabolism, were recently reported to be associated with plasma levels of lipids and C-reactive protein (CRP) among populations of mostly European descent. The aim of the present study was to investigate whether the PPP1R3B variants are associated with plasma levels of lipids and inflammation factors in Chinese Han.
Five single nucleotide polymorphisms (SNPs) of the PPP1R3B gene were genotyped and their associations with plasma lipids and CRP were determined in 1636 Chinese Han from Shanghai.
Three SNPs, namely rs2126259, rs9987289, and rs19334, were significantly associated with plasma levels of low-density lipoprotein-cholesterol, and rs2126259 and rs9987289 were further significantly associated with total cholesterol. The remaining two SNPs (rs189798 and rs330919) were significantly associated with plasma CRP levels, but not with plasma lipid levels.
Genetic polymorphisms of the PPP1R3B gene may contribute to variations in plasma lipids and CRP levels among Chinese Han individuals.
PPP1R3B 基因编码参与肝糖原代谢的关键蛋白，其遗传变异与欧洲血统人群的血脂和 C 反应蛋白（CRP）水平有关。本研究旨在探讨 PPP1R3B 变异是否与中国汉族人群的血脂和炎症因子水平相关。
对来自上海的 1636 例中国汉族人群的 PPP1R3B 基因的 5 个单核苷酸多态性（SNP）进行基因分型，并检测其与血浆脂质和 CRP 的相关性。
3 个 SNP（rs2126259、rs9987289 和 rs19334）与低密度脂蛋白胆固醇水平显著相关，rs2126259 和 rs9987289 与总胆固醇水平进一步显著相关。其余两个 SNP（rs189798 和 rs330919）与 CRP 水平显著相关，但与血脂水平无关。
PPP1R3B 基因的遗传多态性可能导致中国汉族人群血浆脂质和 CRP 水平的差异。
