Department of Neuroscience and Behavior of the Ribeirão Preto Medical School, University of São Paulo, INCT Translational Medicine (CNPq), São Paulo, Brazil.
J Psychopharmacol. 2013 Mar;27(3):312-6. doi: 10.1177/0269881112474524. Epub 2013 Jan 23.
Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle.
The objective of this paper is to assess the effects on sleep of acute systemic administration of CBD.
Adult male Wistar rats were randomly distributed into four groups that received intraperitoneal injections of CBD 2.5 mg/kg, CBD 10 mg/kg, CBD 40 mg/kg or vehicle (n=seven animals/group). Sleep recordings were made during light and dark periods for four days: two days of baseline recording, one day of drug administration (test), and one day after drug (post-test).
During the light period of the test day, the total percentage of sleep significantly increased in the groups treated with 10 and 40 mg/kg of CBD compared to placebo. REM sleep latency increased in the group injected with CBD 40 mg/kg and was significantly decreased with the dose of 10 mg/kg on the post-test day. There was an increase in the time of SWS in the group treated with CBD 40 mg/kg, although this result did not reach statistical significance.
The systemic acute administration of CBD appears to increase total sleep time, in addition to increasing sleep latency in the light period of the day of administration.
大麻二酚（CBD）是大麻的主要成分之一，具有广泛的作用谱，包括对睡眠-觉醒周期的影响。
本文旨在评估 CBD 全身给药对睡眠的影响。
成年雄性 Wistar 大鼠随机分为四组，分别接受腹腔注射 CBD2.5mg/kg、CBD10mg/kg、CBD40mg/kg 或载体（每组 7 只动物）。在四天的光暗周期内进行睡眠记录：两天基线记录，一天药物给药（测试），一天药物后（测试后）。
在测试日的光照期，与安慰剂相比，10mg/kg 和 40mg/kg CBD 治疗组的总睡眠时间百分比显著增加。40mg/kg CBD 注射组的 REM 睡眠潜伏期增加，而在测试后一天，10mg/kg CBD 剂量的 REM 睡眠潜伏期显著降低。40mg/kg CBD 治疗组的 SWS 时间增加，尽管这一结果没有达到统计学意义。
CBD 的全身急性给药似乎增加了总睡眠时间，并增加了给药日白天的睡眠潜伏期。
