谷胱甘肽系统在颞叶癫痫中的相关性：在人类和实验模型中的证据。
Relevance of the glutathione system in temporal lobe epilepsy: evidence in human and experimental models.
机构信息
Laboratory of Neurochemistry, National Institute of Pediatrics, 04530 Mexico City, Mexico.
Laboratory of Neuroplasticity and Neurodegeneration, CINVESTAV, 07360 Mexico City, Mexico.
出版信息
Oxid Med Cell Longev. 2014;2014:759293. doi: 10.1155/2014/759293. Epub 2014 Nov 30.
Abstract
Oxidative stress, which is a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with diseases that are systemic as well as diseases that affect the central nervous system. Epilepsy is a chronic neurological disorder, and temporal lobe epilepsy represents an estimated 40% of all epilepsy cases. Currently, evidence from human and experimental models supports the involvement of oxidative stress during seizures and in the epileptogenesis process. Hence, the aim of this review was to provide information that facilitates the processing of this evidence and investigate the therapeutic impact of the biochemical status for this specific pathology.
摘要
氧化应激是一种活性氧和氮产生失衡的状态，由多种因素引起。这种生化状态与全身性疾病以及影响中枢神经系统的疾病有关。癫痫是一种慢性神经系统疾病，而颞叶癫痫约占所有癫痫病例的 40%。目前，来自人类和实验模型的证据支持氧化应激在癫痫发作和癫痫形成过程中的参与。因此，本综述的目的是提供有助于处理这一证据的信息，并研究这种特定病理的生化状态的治疗影响。
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