抗体依赖的细胞介导的病毒抑制抗体活性与 HIV-1 超感染风险无关。
Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection.
机构信息
Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92967, USA.
出版信息
J Acquir Immune Defic Syndr. 2013 May 1;63(1):31-3. doi: 10.1097/QAI.0b013e3182874d41.
Abstract
Previous studies of HIV-infected women with high-risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection with a different HIV-1 strain. Here, we measured antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity in the plasma of 12 superinfected cases and 36 singly infected matched controls against 2 heterologous viruses. We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1.
摘要
先前对具有高危行为的 HIV 感染女性的研究表明，初始 HIV-1 感染引起的中和抗体和细胞免疫均与防止不同 HIV-1 株的再次感染无关。在这里，我们测量了 12 例再次感染病例和 36 例匹配的单次感染对照者的血浆中抗体依赖性细胞介导的病毒抑制（ADCVI）抗体活性，以针对 2 种异源病毒。我们未发现血浆 ADCVI 活性与再感染状态之间存在关联。由原始感染引起的异源病毒的 ADCVI 抗体活性可能无助于预防再次感染 HIV-1。
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