College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, P. R., China.
Int J Numer Method Biomed Eng. 2013 Mar;29(3):351-62. doi: 10.1002/cnm.2508. Epub 2012 Aug 25.
The extracardiac Fontan connection (EFC) is an effective treatment for congenital single ventricle heart defects. Numerous studies have sought to optimize the EFC design. However, the optimal design of EFC remains uncertain. This study aims to examine the influence of bypass angles between the inferior vena cava (IVC) and right pulmonary artery (RPA), and the angles between the IVC and superior vena cava (SVC), on hemodynamics. Furthermore, this study demonstrates a methodology for cardiovascular surgical planning. First, a three-dimensional anatomical geometry was reconstructed from the medical images of a patient with single ventricle heart defects. Second, based on haptic deformations, six computational models were virtually generated. Third, numerical simulations were conducted using computational fluid dynamics through the finite volume method. Finally, hemodynamic parameters were obtained and evaluated. The hemodynamic parameters, including the flow patterns, streamlines, and swirling flow, were obtained. Meanwhile, the energy loss and flow distributions of vena cava blood were calculated. First, the hepatic artery blood distribution to two lungs and the flow ratio of the left pulmonary artery to RPA are sensitive to the angle between the IVC and RPA and not to that between the IVC and SVC. Second, energy dissipation is mainly sensitive to the angle between the IVC and SVC and not to that between the IVC and RPA. Third, an appropriate increase in the angle between the IVC and RPA or that between the IVC and SVC may lead to optimal options. This study is useful for surgeons in evaluating optimal Fontan options.
心外腔 Fontan 连接(EFC)是治疗先天性单心室心脏缺陷的有效方法。许多研究都试图优化 EFC 的设计。然而,EFC 的最佳设计仍然不确定。本研究旨在探讨下腔静脉(IVC)与右肺动脉(RPA)之间的旁路角度,以及 IVC 与上腔静脉(SVC)之间的角度对血液动力学的影响。此外,本研究还展示了一种心血管手术规划方法。首先,从单心室心脏缺陷患者的医学图像重建了三维解剖几何结构。其次,基于触觉变形,虚拟生成了六个计算模型。第三,通过有限体积法使用计算流体动力学进行数值模拟。最后,获得并评估了血液动力学参数。获得了血流模式、流线和涡流等血液动力学参数,同时计算了腔静脉血液的能量损失和流量分布。首先,肝总动脉血流分配到两个肺和左肺动脉与 RPA 的血流比对 IVC 和 RPA 之间的角度敏感,而对 IVC 和 SVC 之间的角度不敏感。其次,能量耗散主要对 IVC 和 SVC 之间的角度敏感,而对 IVC 和 RPA 之间的角度不敏感。第三,适当增加 IVC 和 RPA 之间或 IVC 和 SVC 之间的角度可能会导致最佳选择。本研究对评估最佳 Fontan 选择的外科医生有用。