Bioengineering Center, Wayne State University, 818 W. Hancock, Detroit, MI 48201, USA.
Int J Numer Method Biomed Eng. 2013 Mar;29(3):392-407. doi: 10.1002/cnm.2518. Epub 2012 Sep 29.
A series of computational studies were performed to investigate the biomechanical responses of the pig head under a specific shock tube environment. A finite element model of the head of a 50-kg Yorkshire pig was developed with sufficient details, based on the Lagrangian formulation, and a shock tube model was developed using the multimaterial arbitrary Lagrangian-Eulerian (MMALE) approach. These two models were integrated and a fluid/solid coupling algorithm was used to simulate the interaction of the shock wave with the pig's head. The finite element model-predicted incident and intracranial pressure traces were in reasonable agreement with those obtained experimentally. Using the verified numerical model of the shock tube and pig head, further investigations were carried out to study the spatial and temporal distributions of pressure, shear stress, and principal strain within the head. Pressure enhancement was found in the skull, which is believed to be caused by shock wave reflection at the interface of the materials with distinct wave impedances. Brain tissue has a shock attenuation effect and larger pressures were observed in the frontal and occipital regions, suggesting a greater possibility of coup and contrecoup contusion. Shear stresses in the brain and deflection in the skull remained at a low level. Higher principal strains were observed in the brain near the foramen magnum, suggesting that there is a greater chance of cellular or vascular injuries in the brainstem region.
进行了一系列计算研究,以调查猪头部在特定的激波管环境下的生物力学响应。根据拉格朗日公式,对头骨进行了详细的有限元建模,并使用多物质任意拉格朗日-欧拉(MMALE)方法对头骨的激波管模型进行了开发。将这两个模型集成,并使用流固耦合算法来模拟冲击波与猪头部的相互作用。有限元模型预测的入射压力和颅内压力轨迹与实验获得的压力轨迹吻合较好。利用验证的激波管和猪头部的数值模型,进一步研究了压力、剪应力和主应变在头部内的时空分布。在颅骨中发现了压力增强,这被认为是由于冲击波在具有明显波阻抗的材料界面处的反射所致。脑组织具有减震作用,并且在前额和枕部区域观察到更大的压力,这表明更有可能发生冲击伤和对冲伤。大脑中的剪应力和颅骨的挠度仍保持在较低水平。在靠近枕骨大孔的大脑中观察到更高的主应变,这表明在脑干区域细胞或血管损伤的可能性更大。