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症状性硬化性血管瘤:一名年轻女孩罕见的孤立性肺结节病例。

Symptomatic sclerosing haemangioma: a rare case of solitary pulmonary nodule in a young girl.

作者信息

Goel Madhu Mati, Kumari Malti, Singh Sushil Kumar, Soren Vijay

机构信息

Department of Pathology, CSM Medical University, Lucknow, Uttar Pradesh, India.

出版信息

BMJ Case Rep. 2013 Jan 22;2013:bcr2012007072. doi: 10.1136/bcr-2012-007072.

Abstract

Sclerosing haemangioma (SH) is a rare benign lung tumour with distinctive variety of histological patterns. SH typically presents as asymptomatic peripheral, solitary well-circumscribed lesion in women with median age at diagnosis in the fifth decade. Preoperative diagnosis of this tumour is difficult, and sometimes even intraoperative frozen sections cannot differentiate it from malignant tumours. Here, we present our experiences in investigating its characteristics. We report a case of a 19-year-old girl who presented with chest pain, cough and sputum and off and on haemoptysis for 6 months. Anti-tubercular treatment was given but provided no relief. CT chest showed a well-defined hypodense solid mass lesion with a soft tissue alternation. Lobectomy was performed. Microscopy revealed a tumour comprising of two distinct populations of cells surface and stromal cells which disposed in papillary, solid, sclerotic and haemorrhagic growth patterns. Histology and immunohistochemistry confirmed the diagnosis of SH of the lung.

摘要

硬化性血管瘤(SH)是一种罕见的肺部良性肿瘤,具有独特多样的组织学模式。SH通常表现为无症状的外周孤立性边界清晰的病变,多见于女性,诊断时的中位年龄在50岁左右。该肿瘤术前诊断困难,有时甚至术中冰冻切片也无法将其与恶性肿瘤区分开来。在此,我们介绍我们对其特征进行研究的经验。我们报告一例19岁女孩,她出现胸痛、咳嗽、咳痰及间断咯血6个月。给予抗结核治疗但症状未缓解。胸部CT显示一个边界清晰的低密度实性肿块病变,伴有软组织改变。行肺叶切除术。显微镜检查显示肿瘤由两种不同类型的细胞组成,即表面细胞和基质细胞,它们呈乳头状、实性、硬化性和出血性生长模式。组织学和免疫组化确诊为肺硬化性血管瘤。

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